'Perfect for some but disastrous for others': Patients and clinicians express concerns over phone and video consultations

A study of rheumatology patients and clinicians has found that while the majority found phone or video consultations more convenient than face-to-face consultations, they viewed so-called telemedicine as less diagnostically accurate than in-person consultations and as having the potential to increase health inequalities and barriers to accessing appropriate care.
A key finding was that the vast majority of respondents — 86% of patients and 93% of clinicians — felt that telemedicine was worse than face-to-face consultations for accuracy of assessment, with some reporting misdiagnoses.
One rheumatology patient explained: “My rheumatologist cannot see or hear how I move, look at my skin, eyes, hair, hands, bones, how I am…I was diagnosed with something over the phone, which I know isn’t right, and it’s getting worse.”
Melanie Sloan, lead author from the Primary Care Unit at the University of Cambridge, said: “The pandemic has had a major impact on the ability of healthcare professionals to see their patients face-to-face, and this has led to a significant increase in the number of telemedicine consultations. While these are undeniably safer in terms of COVID risk, there had been little research previously on the impact on patient care, particularly for more complex conditions.”
In a study published today in Rheumatology, researchers at the University of Cambridge, working with a wider national team including expert consultants, patients and psychologists, examined the pitfalls and benefits of telemedicine for patients with chronic diseases.
Between April 2021 and July 2021, a total of 1,340 patients and 111 clinicians completed online surveys. The team also conducted in-depth interviews with 31 patients and 29 clinicians. The majority of patients were from the UK (96%) and had inflammatory arthritis (32%) or lupus (32%).

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Chemo helps breast cancer cells get their ‘foot in the door’ to the lungs

A new study adds to the evidence that chemotherapy enhances cancer’s spread beyond the primary tumor, showing how one chemo drug allows breast cancer cells to squeeze through and attach to blood vessel linings in the lungs.
The research in mice leaves no doubt that the chemo drug caused changes to non-cancer cells that enable this process. Scientists pre-treated healthy mice with the chemotherapy agent and gave them intravenous injections of breast cancer cells four days later.
Within three hours of injection, the cancer cells were penetrating weakened junctions between blood vessel cells in the lungs and binding to those vessels’ underlining structure — avoiding being washed away by blood flow.
“This is the key step giving cancer cells a foot in the door at a secondary site,” said Tsonwin Hai, professor of biological chemistry and pharmacology at The Ohio State University and senior author of the study. “The whole point of our pre-treatment model is to ask the question: Does chemotherapy affect normal cells in such a way that they will turn around and help cancer cells? The answer is yes.
“It’s a cautionary note for the use of chemotherapy.”
The study was published online recently in the International Journal of Molecular Sciences.

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Abnormal brain changes over time with bipolar disorder

Bipolar disorder (BD) is a debilitating psychiatric disorder characterized by fluctuating periods of depression and mania. Researchers have long suspected that BD may be accompanied by abnormal structural and functional changes in the brain. Small cross-sectional brain imaging studies of people with BD have shown hints at those changes, but the ability to interpret data collected at a single timepoint is limited. Now, a multi-center longitudinal study shows aberrant changes over time in the brains of people with BD. Some changes were specifically associated with more episodes of mania.
The report appears in Biological Psychiatry, published by Elsevier. The study involved a large international multi-center team of more than 70 researchers from the ENIGMA Bipolar Disorder Working Group.
“The ENIGMA Bipolar Disorder Working Group report illustrates the power of large-scale multi-center collaboration,” said John Krystal, MD, Editor of Biological Psychiatry. “Longitudinal neuroimaging studies are extremely challenging to conduct. Here, by combining data from 14 sites, we get one of the clearest pictures we have of the neurotoxic impact of bipolar disorder, particularly manic episodes.”
The researchers gathered magnetic resonance imaging (MRI) and detailed clinical data from 307 people with BD and from 925 healthy controls (HC) from 14 clinical sites worldwide. Participants were assessed at two timepoints, ranging from six months to nine years apart.
The most striking finding was that the cortex, the brain’s outermost layer, thinned over time to a greater extent in people who experienced more manic episodes. Those who did not have mania showed no cortical thinning or even cortical thickening. The changes were most evident in the prefrontal cortex (PFC), an area associated with executive control and emotion regulation.
“The fact that cortical thinning in patients related to manic episodes stresses the importance of treatment to prevent mood episodes and is important information for psychiatrists,” said senior author Mikael Landén, MD, PhD, Professor and Chief Physician at the Institute of Neuroscience and Physiology, University of Gothenburg, Sweden. “Researchers should focus on better understanding the progressive mechanisms at play in bipolar disorder to ultimately improve treatment options.”
Compared to HC, people with BD showed a faster enlargement in the brain’s ventricles, cavities within the brain that contain cerebrospinal fluid. In cortical areas outside the PFC, BD participants actually showed slower thinning than HC participants.
Lead author Christoph Abé, PhD, Assistant Professor, Karolinska Institutet, Sweden, said: “The abnormal ventricle enlargements and importantly the associations between cortical thinning and manic symptoms indicate that bipolar disorder may in fact be a neuroprogressive disorder, which could explain the worsening of bipolar symptoms in some patients.”
One possibility to explain why BD patients may have slower thinning of the cortex compared to HC is that lithium, a medication used to treat BD, is known to have neuroprotective effects and could bolster cortical thickness. Regardless, the study provides new clues about the structural effects of BD on the brain over time.
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Materials provided by Elsevier. Note: Content may be edited for style and length.

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Covid shots for younger children could begin days after a C.D.C. panel meets.

Is the Pfizer-BioNTech vaccine safe for children ages 5 to 11? Does it work? Does every child need it?The Food and Drug Administration on Friday authorized the vaccine for emergency use in those age groups, following a near-unanimous recommendation from its advisers last week. On Tuesday, a similar committee advising the Centers for Disease Control and Prevention will have its say.If, as expected, the advisers recommend the vaccine and the agency’s director, Dr. Rochelle Walensky, signs off, the decision would most likely ease the worries of millions of parents and buttress the United States’ defenses against the virus before winter arrives.Inoculations for children ages 5 through 11 could then begin this week. Anticipating the agency’s decision, the Biden administration has enlisted more than 20,000 pediatricians, family doctors and pharmacies to administer the vaccines.About 15 million doses are already being packed with dry ice, loaded into small specialized containers and shipped via airplanes and trucks to vaccination sites across the country, federal officials said on Monday.The younger children will receive one-third of the dose authorized for those 12 and older, delivered by smaller needles and stored in smaller vials to avoid a mix-up with adult doses.The C.D.C.’s guidelines for the vaccine’s use are not legally binding, but heavily influence the medical community’s practice. An endorsement would be timely, as Americans begin to plan for the winter holidays.Although cases in the United States have been falling steadily for weeks, experts warn that indoor family gatherings during the Thanksgiving and Christmas holidays may send the rates soaring again, even if not to the horrific highs of last year. Airlines are preparing for what may be the busiest travel season since the start of the pandemic.Vaccinations would ease the minds of many parents who are anxious to protect their young children and frustrated by frequent school shutdowns and quarantines. Outbreaks of the coronavirus forced 2,000 schools to close between early August and October.Still, many parents are hesitant to immunize their children, citing concerns about long-term safety of the vaccine or because they fear that the vaccine is more harmful than Covid-19..css-1kpebx{margin:0 auto;font-family:nyt-franklin,helvetica,arial,sans-serif;font-weight:700;font-size:1.125rem;line-height:1.3125rem;color:#121212;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-family:nyt-cheltenham,georgia,’times new roman’,times,serif;font-weight:700;font-size:1.375rem;line-height:1.625rem;}@media (min-width:740px){#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-size:1.6875rem;line-height:1.875rem;}}@media (min-width:740px){.css-1kpebx{font-size:1.25rem;line-height:1.4375rem;}}.css-1gtxqqv{margin-bottom:0;}.css-k59gj9{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-flex-direction:column;-ms-flex-direction:column;flex-direction:column;width:100%;}.css-1e2usoh{font-family:inherit;display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-webkit-justify-content:space-between;-ms-flex-pack:justify;justify-content:space-between;border-top:1px solid #ccc;padding:10px 0px 10px 0px;background-color:#fff;}.css-1jz6h6z{font-family:inherit;font-weight:bold;font-size:1rem;line-height:1.5rem;text-align:left;}.css-1t412wb{box-sizing:border-box;margin:8px 15px 0px 15px;cursor:pointer;}.css-hhzar2{-webkit-transition:-webkit-transform ease 0.5s;-webkit-transition:transform ease 0.5s;transition:transform ease 0.5s;}.css-t54hv4{-webkit-transform:rotate(180deg);-ms-transform:rotate(180deg);transform:rotate(180deg);}.css-1r2j9qz{-webkit-transform:rotate(0deg);-ms-transform:rotate(0deg);transform:rotate(0deg);}.css-e1ipqs{font-size:1rem;line-height:1.5rem;padding:0px 30px 0px 0px;}.css-e1ipqs a{color:#326891;-webkit-text-decoration:underline;text-decoration:underline;}.css-e1ipqs a:hover{-webkit-text-decoration:none;text-decoration:none;}.css-1o76pdf{visibility:show;height:100%;padding-bottom:20px;}.css-1sw9s96{visibility:hidden;height:0px;}.css-1in8jot{background-color:white;border:1px solid #e2e2e2;width:calc(100% – 40px);max-width:600px;margin:1.5rem auto 1.9rem;padding:15px;box-sizing:border-box;font-family:’nyt-franklin’,arial,helvetica,sans-serif;text-align:left;}@media (min-width:740px){.css-1in8jot{padding:20px;width:100%;}}.css-1in8jot:focus{outline:1px solid #e2e2e2;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1in8jot{border:none;padding:10px 0 0;border-top:2px solid #121212;}What to Know About Covid-19 Booster ShotsThe F.D.A. has authorized booster shots for millions of recipients of the Pfizer-BioNTech, Moderna and Johnson & Johnson vaccines. Pfizer and Moderna recipients who are eligible for a booster include people 65 and older, and younger adults at high risk of severe Covid-19 because of medical conditions or where they work. Eligible Pfizer and Moderna recipients can get a booster at least six months after their second dose. All Johnson & Johnson recipients will be eligible for a second shot at least two months after the first.Yes. The F.D.A. has updated its authorizations to allow medical providers to boost people with a different vaccine than the one they initially received, a strategy known as “mix and match.” Whether you received Moderna, Johnson & Johnson or Pfizer-BioNTech, you may receive a booster of any other vaccine. Regulators have not recommended any one vaccine over another as a booster. They have also remained silent on whether it is preferable to stick with the same vaccine when possible.The C.D.C. has said the conditions that qualify a person for a booster shot include: hypertension and heart disease; diabetes or obesity; cancer or blood disorders; weakened immune system; chronic lung, kidney or liver disease; dementia and certain disabilities. Pregnant women and current and former smokers are also eligible.The F.D.A. authorized boosters for workers whose jobs put them at high risk of exposure to potentially infectious people. The C.D.C. says that group includes: emergency medical workers; education workers; food and agriculture workers; manufacturing workers; corrections workers; U.S. Postal Service workers; public transit workers; grocery store workers.Yes. The C.D.C. says the Covid vaccine may be administered without regard to the timing of other vaccines, and many pharmacy sites are allowing people to schedule a flu shot at the same time as a booster dose.About three in 10 parents say they will definitely not get the vaccine for their 5- to 11-year-old children, according to the most recent poll by the Kaiser Family Foundation. A similar percentage of parents said that they would immunize their children “right away,” a figure that has barely budged since similar polls in July and September.Before the F.D.A. advisers met last week, they were bombarded by thousands of emails spouting misinformation about the vaccine and asking the experts to vote against it. One common objection to the vaccine holds that children rarely get sick from the virus, and the vaccine’s potential harms may outweigh its benefits.But while children are much less likely than adults to become seriously ill from the virus, their risk is not zero. Many children were infected with the coronavirus in the most recent surge, and children ages 5 through 11 accounted for nearly 11 percent of all cases the week of Oct. 10, according to data collected by the C.D.C.Since the beginning of the pandemic, more than 8,300 children ages 5 to 11 have been hospitalized with Covid, and at least 94 have died. About one-third of the hospitalized children were sick enough to be admitted to intensive care units.

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Covid Shots for Children 5 to 11 Could Begin Days After a C.D.C. Panel Meets

Is the Pfizer-BioNTech vaccine safe for children ages 5 to 11? Does it work? Does every child need it?The Food and Drug Administration on Friday authorized the vaccine for emergency use in those age groups, following a near-unanimous recommendation from its advisers last week. On Tuesday, a similar committee advising the Centers for Disease Control and Prevention will have its say.If, as expected, the advisers recommend the vaccine and the agency’s director, Dr. Rochelle Walensky, signs off, the decision would most likely ease the worries of millions of parents and buttress the United States’ defenses against the virus before winter arrives.Inoculations for children ages 5 through 11 could then begin this week. Anticipating the agency’s decision, the Biden administration has enlisted more than 20,000 pediatricians, family doctors and pharmacies to administer the vaccines.About 15 million doses are already being packed with dry ice, loaded into small specialized containers and shipped via airplanes and trucks to vaccination sites across the country, federal officials said on Monday.The younger children will receive one-third of the dose authorized for those 12 and older, delivered by smaller needles and stored in smaller vials to avoid a mix-up with adult doses.The C.D.C.’s guidelines for the vaccine’s use are not legally binding, but heavily influence the medical community’s practice. An endorsement would be timely, as Americans begin to plan for the winter holidays.Although cases in the United States have been falling steadily for weeks, experts warn that indoor family gatherings during the Thanksgiving and Christmas holidays may send the rates soaring again, even if not to the horrific highs of last year. Airlines are preparing for what may be the busiest travel season since the start of the pandemic.Vaccinations would ease the minds of many parents who are anxious to protect their young children and frustrated by frequent school shutdowns and quarantines. Outbreaks of the coronavirus forced 2,000 schools to close between early August and October.Still, many parents are hesitant to immunize their children, citing concerns about long-term safety of the vaccine or because they fear that the vaccine is more harmful than Covid-19..css-1kpebx{margin:0 auto;font-family:nyt-franklin,helvetica,arial,sans-serif;font-weight:700;font-size:1.125rem;line-height:1.3125rem;color:#121212;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-family:nyt-cheltenham,georgia,’times new roman’,times,serif;font-weight:700;font-size:1.375rem;line-height:1.625rem;}@media (min-width:740px){#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-size:1.6875rem;line-height:1.875rem;}}@media (min-width:740px){.css-1kpebx{font-size:1.25rem;line-height:1.4375rem;}}.css-1gtxqqv{margin-bottom:0;}.css-k59gj9{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-flex-direction:column;-ms-flex-direction:column;flex-direction:column;width:100%;}.css-1e2usoh{font-family:inherit;display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-webkit-justify-content:space-between;-ms-flex-pack:justify;justify-content:space-between;border-top:1px solid #ccc;padding:10px 0px 10px 0px;background-color:#fff;}.css-1jz6h6z{font-family:inherit;font-weight:bold;font-size:1rem;line-height:1.5rem;text-align:left;}.css-1t412wb{box-sizing:border-box;margin:8px 15px 0px 15px;cursor:pointer;}.css-hhzar2{-webkit-transition:-webkit-transform ease 0.5s;-webkit-transition:transform ease 0.5s;transition:transform ease 0.5s;}.css-t54hv4{-webkit-transform:rotate(180deg);-ms-transform:rotate(180deg);transform:rotate(180deg);}.css-1r2j9qz{-webkit-transform:rotate(0deg);-ms-transform:rotate(0deg);transform:rotate(0deg);}.css-e1ipqs{font-size:1rem;line-height:1.5rem;padding:0px 30px 0px 0px;}.css-e1ipqs a{color:#326891;-webkit-text-decoration:underline;text-decoration:underline;}.css-e1ipqs a:hover{-webkit-text-decoration:none;text-decoration:none;}.css-1o76pdf{visibility:show;height:100%;padding-bottom:20px;}.css-1sw9s96{visibility:hidden;height:0px;}.css-1in8jot{background-color:white;border:1px solid #e2e2e2;width:calc(100% – 40px);max-width:600px;margin:1.5rem auto 1.9rem;padding:15px;box-sizing:border-box;font-family:’nyt-franklin’,arial,helvetica,sans-serif;text-align:left;}@media (min-width:740px){.css-1in8jot{padding:20px;width:100%;}}.css-1in8jot:focus{outline:1px solid #e2e2e2;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1in8jot{border:none;padding:10px 0 0;border-top:2px solid #121212;}What to Know About Covid-19 Booster ShotsThe F.D.A. has authorized booster shots for millions of recipients of the Pfizer-BioNTech, Moderna and Johnson & Johnson vaccines. Pfizer and Moderna recipients who are eligible for a booster include people 65 and older, and younger adults at high risk of severe Covid-19 because of medical conditions or where they work. Eligible Pfizer and Moderna recipients can get a booster at least six months after their second dose. All Johnson & Johnson recipients will be eligible for a second shot at least two months after the first.Yes. The F.D.A. has updated its authorizations to allow medical providers to boost people with a different vaccine than the one they initially received, a strategy known as “mix and match.” Whether you received Moderna, Johnson & Johnson or Pfizer-BioNTech, you may receive a booster of any other vaccine. Regulators have not recommended any one vaccine over another as a booster. They have also remained silent on whether it is preferable to stick with the same vaccine when possible.The C.D.C. has said the conditions that qualify a person for a booster shot include: hypertension and heart disease; diabetes or obesity; cancer or blood disorders; weakened immune system; chronic lung, kidney or liver disease; dementia and certain disabilities. Pregnant women and current and former smokers are also eligible.The F.D.A. authorized boosters for workers whose jobs put them at high risk of exposure to potentially infectious people. The C.D.C. says that group includes: emergency medical workers; education workers; food and agriculture workers; manufacturing workers; corrections workers; U.S. Postal Service workers; public transit workers; grocery store workers.Yes. The C.D.C. says the Covid vaccine may be administered without regard to the timing of other vaccines, and many pharmacy sites are allowing people to schedule a flu shot at the same time as a booster dose.About three in 10 parents say they will definitely not get the vaccine for their 5- to 11-year-old children, according to the most recent poll by the Kaiser Family Foundation. A similar percentage of parents said that they would immunize their children “right away,” a figure that has barely budged since similar polls in July and September.Before the F.D.A. advisers met last week, they were bombarded by thousands of emails spouting misinformation about the vaccine and asking the experts to vote against it. One common objection to the vaccine holds that children rarely get sick from the virus, and the vaccine’s potential harms may outweigh its benefits.But while children are much less likely than adults to become seriously ill from the virus, their risk is not zero. Many children were infected with the coronavirus in the most recent surge, and children ages 5 through 11 accounted for nearly 11 percent of all cases the week of Oct. 10, according to data collected by the C.D.C.Since the beginning of the pandemic, more than 8,300 children ages 5 to 11 have been hospitalized with Covid, and at least 94 have died. About one-third of the hospitalized children were sick enough to be admitted to intensive care units.

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Testosterone Levels: Can Specific Foods or Diets Boost Them?

Can I increase my testosterone levels through the foods I eat? And if so, which foods or diets work best?Many men, particularly as they age, are concerned about their levels of testosterone, the male sex hormone touted to build muscle, sex drive and vigor. But individual foods are unlikely to have an impact on testosterone levels — though drinking excessive amounts of alcohol might. If you are overweight, altering your diet to lose weight may help, since carrying excess pounds is a common cause of low testosterone. But in terms of specific foods or diets, any uptick you achieve may not have a noticeable impact on libido, energy or muscle mass.“If someone was not overweight, I wouldn’t put them on a specific diet to raise testosterone based on the data we have now,” said Alexander Pastuszak, an assistant professor of urology and surgery at the University of Utah in Salt Lake City, who co-authored a review on alternatives to testosterone therapyIn men, normal testosterone levels range from 300 to 1,000 nanograms per deciliter of blood. Ups and downs within that normal range are unlikely to have any impact on sex drive or vitality. Only when levels consistently drop below 300 points — as confirmed in two blood tests by an accredited laboratory — are symptoms like low libido, erectile dysfunction, fatigue, low mood or loss of muscle mass likely to appear, a medical condition known as hypogonadism.Starting at around age 40, men’s testosterone levels start to decline by about 1 percent per year. But the drop can vary tremendously, with some older men maintaining levels similar to healthy young men. The trajectory of falling testosterone is steeper among men who gain a lot of weight, said Dr. Shalender Bhasin, professor of medicine at Harvard and the director of the Research Program in Men’s Health: Aging and Metabolism at Brigham and Women’s Hospital..css-1xzcza9{list-style-type:disc;padding-inline-start:1em;}.css-3btd0c{font-family:nyt-franklin,helvetica,arial,sans-serif;font-size:1rem;line-height:1.375rem;color:#333;margin-bottom:0.78125rem;}@media (min-width:740px){.css-3btd0c{font-size:1.0625rem;line-height:1.5rem;margin-bottom:0.9375rem;}}.css-3btd0c strong{font-weight:600;}.css-3btd0c em{font-style:italic;}.css-1kpebx{margin:0 auto;font-family:nyt-franklin,helvetica,arial,sans-serif;font-weight:700;font-size:1.125rem;line-height:1.3125rem;color:#121212;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-family:nyt-cheltenham,georgia,’times new roman’,times,serif;font-weight:700;font-size:1.375rem;line-height:1.625rem;}@media (min-width:740px){#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-size:1.6875rem;line-height:1.875rem;}}@media (min-width:740px){.css-1kpebx{font-size:1.25rem;line-height:1.4375rem;}}.css-1gtxqqv{margin-bottom:0;}.css-19zsuqr{display:block;margin-bottom:0.9375rem;}.css-12vbvwq{background-color:white;border:1px solid #e2e2e2;width:calc(100% – 40px);max-width:600px;margin:1.5rem auto 1.9rem;padding:15px;box-sizing:border-box;}@media (min-width:740px){.css-12vbvwq{padding:20px;width:100%;}}.css-12vbvwq:focus{outline:1px solid #e2e2e2;}#NYT_BELOW_MAIN_CONTENT_REGION .css-12vbvwq{border:none;padding:10px 0 0;border-top:2px solid #121212;}.css-12vbvwq[data-truncated] .css-rdoyk0{-webkit-transform:rotate(0deg);-ms-transform:rotate(0deg);transform:rotate(0deg);}.css-12vbvwq[data-truncated] .css-eb027h{max-height:300px;overflow:hidden;-webkit-transition:none;transition:none;}.css-12vbvwq[data-truncated] .css-5gimkt:after{content:’See more’;}.css-12vbvwq[data-truncated] .css-6mllg9{opacity:1;}.css-qjk116{margin:0 auto;overflow:hidden;}.css-qjk116 strong{font-weight:700;}.css-qjk116 em{font-style:italic;}.css-qjk116 a{color:#326891;-webkit-text-decoration:underline;text-decoration:underline;text-underline-offset:1px;-webkit-text-decoration-thickness:1px;text-decoration-thickness:1px;-webkit-text-decoration-color:#326891;text-decoration-color:#326891;}.css-qjk116 a:visited{color:#326891;-webkit-text-decoration-color:#326891;text-decoration-color:#326891;}.css-qjk116 a:hover{-webkit-text-decoration:none;text-decoration:none;}Studies on foods or diets and testosterone levels have generally been small and the findings far from conclusive. A recent British review that pooled data from 206 volunteers, for example, found that men on low-fat diets had testosterone levels that were about 60 points higher, on average, than men on high-fat diets. Men who followed a vegetarian diet tended to have the lowest levels of testosterone, about 150 points lower, on average, than those following a high-fat, meat-based diet. Still, Joseph Wittaker, the lead investigator and a nutritionist at the University of Worcester in Britain, said he would not recommend a man increase the fats in his diet unless he had low testosterone levels and symptoms of low T and was already restricting fats.Another study in the Journal of Strength and Conditioning Research tested two styles of diets in 25 fit men between the ages of 18 and 30. Calories consumed were the same, but one group ate a high-fat, very-low-carb, ketogenic-style diet, consisting of 75 percent of calories from fats, 5 percent from carbohydrates and 20 percent from protein. Men in the other group ate a more traditional Western style, low-fat diet, containing 25 percent of calories from fats, 55 percent from carbohydrates and 20 percent from protein. After 10 weeks of eating the high-fat diet, testosterone increased by 118 points, on average, while after the low-fat diet, levels declined by about 36 pointsAileen Son for The New York TimesSimilarly, a study of 3,000 men found that those who reported eating a low-fat diet had slightly lower testosterone levels — about 30 points lower — than men who ate higher-fat diets. But none of the men had low testosterone.“The moral is that healthy men who are of normal weight with no significant comorbidities are unlikely to benefit from restrictive diets,” said Dr. Richard J. Fantus, one of the study’s authors and a urologist at NorthShore University HealthSystem in Evanston, Ill.Diet studies are complicated, because changing one component of the diet, such as fat intake, alters so many other things, such as the amount of carbohydrates, protein and micronutrients consumed. It’s unclear which component of the diet may have prompted the hormonal changes, Dr. Bhasin said. Furthermore, testosterone levels may also be shaped by how much a person sleeps, or whether they are jet-lagged, or if they are eating most of their calories at night or in small meals throughout the day.Dr. Faysal Yafi, chief of the division of Men’s Health and Reconstructive Urology at the University of California, Irvine, says his patients who opt to follow specific diets tend to start exercising more and drinking less alcohol, all of which can raise testosterone levels. He suspects any links between diet and testosterone may be the result of an overall healthier lifestyle.Some men worry that eating lots of soy foods may cause their testosterone levels to fall, because soy is rich in isoflavones, which mimic the structure of estrogen. But the evidence doesn’t support their concerns, even if men eat foods like miso, tofu or soy milk at every meal. (Doctors did report one anecdotal case in which a 19-year-old man with Type 1 diabetes who followed a vegan diet containing 360 milligrams of soy daily — nine times higher than a typical Japanese diet, and 100 times higher than the typical American diet — developed low testosterone levels along with low libido and fatigue. His symptoms improved when he stopped eating the soy-heavy, vegan diet.)Long-term alcohol abuse lowers testosterone by damaging cells in both the testes, which make testosterone, and the liver, which alters testosterone metabolism. But binge drinking every now and then does not appear to have much of an impact — it lowers testosterone for only about 30 minutes, according to one study, after which levels bounce back to baseline.Obese men who have low levels of testosterone can increase levels by cutting calories and losing weight — the type of diet does not matter, studies suggest. On the opposite extreme, Dr. Bhasin said he is seeing an increasing number of men at his clinic who have body dysmorphic issues and are suffering from low libido and fatigue. Strict calorie restriction, exercising intensely and being chronically stressed can all cause testosterone levels to plummet and are likely to blame, he said.The bottom line is that for otherwise healthy men who are following a reasonably healthy lifestyle, fiddling with specific foods or the composition of the diet is not likely to make much of a difference on the testosterone score card. As Dr. Fantus of NorthShore University put it: “I don’t think there is a way to game the system to get really large increases by changing the diet.”

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How to Host Thanksgiving With Unvaccinated Friends and Family

We asked the experts for guidance on staying safe and keeping the peace.In addition to the big, juicy turkey on the table, there’s also an elephant lurking in the room this Thanksgiving: the vaccination status of your guests.It’s a tricky thing to talk about. Do you ask your aunt if she received the Covid vaccine after she R.S.V.P.s? What if she says no? Do you endure another scaled-back celebration, like last year? Or should you serve up a bunch of precautions?According to a Marist Poll published in September, most Americans (nearly 80 percent) say they have gotten or will get a Covid vaccine, but nearly 20 percent still say they do not intend to be vaccinated.That doesn’t sit well with some of the people who have already rolled up their sleeves. A recent Harris Poll found that half of the more than 1,400 vaccinated respondents were either “extremely” or “considerably” hesitant to spend the holidays with unvaccinated family members or friends.For some, the risk of celebrating with unvaccinated friends and relatives just isn’t worth it. But if you’re open to gathering with a mixed vaccination status group, there are ways to do it cautiously, experts say.“Be not afraid, but be reasonable,” said Dr. Juan C. Salazar, a pediatric infectious diseases specialist and physician-in-chief of Connecticut Children’s in Hartford, Conn. You can still get together, he said, but each family will need to ask one crucial question: “What is the likelihood that we will get very sick from Covid-19?”If you’re uncertain of how to proceed (or whether you ought to gather at all) we asked several experts for ideas on how to make Thanksgiving safer for everyone.Make it a shared problem to be solved.Start by calling your unvaccinated family members and soliciting their ideas on how to gather safely, said Daniel L. Shapiro, an associate professor of psychology at Harvard Medical School and the author of “Negotiating the Nonnegotiable: How to Resolve Your Most Emotionally Charged Conflicts.”Ask: “What’s your advice on how we can make sure everyone feels safe and comfortable when we get together?” he suggested. Then come up with some ideas. Perhaps you suggest that there should be mandatory testing right before dinner, or that you should gather outside, near a patio heater.“Try not to judge any ideas right away,” Dr. Shapiro advised. “Some ideas will be better than others, and by brainstorming together as a family, everyone can take more ownership over the chosen idea. A warning, though: If you go this route, make sure you stick to joint brainstorming and don’t slip into political debate.”Use rapid testing to reduce risk.According to the Centers for Disease Control and Prevention, taking a coronavirus test ahead of a holiday celebration can reduce the risk of spreading the virus, particularly when people from multiple households and different parts of the country mix.Rapid antigen tests, which can indicate within minutes whether someone is contagious with Covid-19, are the best options, said Dr. Michael J. Mina, an epidemiologist at the Harvard T.H. Chan School of Public Health and a co-author of a recent New York Times editorial about the usefulness of home testing.“Everyone knows if they come to my house, they are going to be tested,” he said.Dr. Mina, who is hosting Thanksgiving dinner this year (and also has a newborn), will offer rapid antigen home tests to each of his guests, regardless of their vaccination status — and his family will use them as well. Any guests who are positive will need to leave.Taking the test just before entering someone’s home is ideal, because the results only reflect whether you have a lot of virus in your nose at that very moment, he added.If your family members balk at the idea, remind them that an infected person can easily spread the virus to other people, even if they don’t have symptoms. And while the vaccine is very good at protecting against severe illness and death, the latest data suggest that immunity against infection may be slowly waning for vaccinated people.“If a rapid test says you’re positive, then that is a very reliable indication that you are infected and infectious,” said Eleanor Murray, an epidemiologist at the Boston University School of Public Health. “You should not be around other people.”Rapid tests are sometimes in short supply, but can be found at retailers like Amazon, Walmart, Kroger, CVS or Walgreens, both online and in stores. Many of them are pricey, often costing around $24 for two tests..css-1kpebx{margin:0 auto;font-family:nyt-franklin,helvetica,arial,sans-serif;font-weight:700;font-size:1.125rem;line-height:1.3125rem;color:#121212;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-family:nyt-cheltenham,georgia,’times new roman’,times,serif;font-weight:700;font-size:1.375rem;line-height:1.625rem;}@media (min-width:740px){#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-size:1.6875rem;line-height:1.875rem;}}@media (min-width:740px){.css-1kpebx{font-size:1.25rem;line-height:1.4375rem;}}.css-1gtxqqv{margin-bottom:0;}.css-k59gj9{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-flex-direction:column;-ms-flex-direction:column;flex-direction:column;width:100%;}.css-1e2usoh{font-family:inherit;display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-webkit-justify-content:space-between;-ms-flex-pack:justify;justify-content:space-between;border-top:1px solid #ccc;padding:10px 0px 10px 0px;background-color:#fff;}.css-1jz6h6z{font-family:inherit;font-weight:bold;font-size:1rem;line-height:1.5rem;text-align:left;}.css-1t412wb{box-sizing:border-box;margin:8px 15px 0px 15px;cursor:pointer;}.css-hhzar2{-webkit-transition:-webkit-transform ease 0.5s;-webkit-transition:transform ease 0.5s;transition:transform ease 0.5s;}.css-t54hv4{-webkit-transform:rotate(180deg);-ms-transform:rotate(180deg);transform:rotate(180deg);}.css-1r2j9qz{-webkit-transform:rotate(0deg);-ms-transform:rotate(0deg);transform:rotate(0deg);}.css-e1ipqs{font-size:1rem;line-height:1.5rem;padding:0px 30px 0px 0px;}.css-e1ipqs a{color:#326891;-webkit-text-decoration:underline;text-decoration:underline;}.css-e1ipqs a:hover{-webkit-text-decoration:none;text-decoration:none;}.css-1o76pdf{visibility:show;height:100%;padding-bottom:20px;}.css-1sw9s96{visibility:hidden;height:0px;}.css-1in8jot{background-color:white;border:1px solid #e2e2e2;width:calc(100% – 40px);max-width:600px;margin:1.5rem auto 1.9rem;padding:15px;box-sizing:border-box;font-family:’nyt-franklin’,arial,helvetica,sans-serif;text-align:left;}@media (min-width:740px){.css-1in8jot{padding:20px;width:100%;}}.css-1in8jot:focus{outline:1px solid #e2e2e2;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1in8jot{border:none;padding:10px 0 0;border-top:2px solid #121212;}What to Know About Covid-19 Booster ShotsThe F.D.A. has authorized booster shots for millions of recipients of the Pfizer-BioNTech, Moderna and Johnson & Johnson vaccines. Pfizer and Moderna recipients who are eligible for a booster include people 65 and older, and younger adults at high risk of severe Covid-19 because of medical conditions or where they work. Eligible Pfizer and Moderna recipients can get a booster at least six months after their second dose. All Johnson & Johnson recipients will be eligible for a second shot at least two months after the first.Yes. The F.D.A. has updated its authorizations to allow medical providers to boost people with a different vaccine than the one they initially received, a strategy known as “mix and match.” Whether you received Moderna, Johnson & Johnson or Pfizer-BioNTech, you may receive a booster of any other vaccine. Regulators have not recommended any one vaccine over another as a booster. They have also remained silent on whether it is preferable to stick with the same vaccine when possible.The C.D.C. has said the conditions that qualify a person for a booster shot include: hypertension and heart disease; diabetes or obesity; cancer or blood disorders; weakened immune system; chronic lung, kidney or liver disease; dementia and certain disabilities. Pregnant women and current and former smokers are also eligible.The F.D.A. authorized boosters for workers whose jobs put them at high risk of exposure to potentially infectious people. The C.D.C. says that group includes: emergency medical workers; education workers; food and agriculture workers; manufacturing workers; corrections workers; U.S. Postal Service workers; public transit workers; grocery store workers.Yes. The C.D.C. says the Covid vaccine may be administered without regard to the timing of other vaccines, and many pharmacy sites are allowing people to schedule a flu shot at the same time as a booster dose.Keep an open mind when talking to relatives about the vaccine.People may decide not to get vaccinated for a variety of reasons, so try not to make assumptions about their rationale, the experts said. Instead, ask questions and listen.If they have a fear of needles (something called trypanophobia, which can occur in adults and kids), perhaps you might ask if you can accompany them to the vaccination site and hold their hand. Or if they say they haven’t been vaccinated because they haven’t had time to schedule an appointment, you might ask if you can assist them in doing that. “That one-on-one conversation approach really does help,” Dr. Murray said.The Pfizer-BioNTech and Moderna vaccines require two shots spaced three or four weeks apart, and full protection comes two weeks after the second dose. If your relatives want one of these vaccines and haven’t yet received a first dose, they’re out of time to get fully vaccinated before Thanksgiving. But there is plenty of time to do it before Christmas — and they can get one shot now, which will provide some protection before Thanksgiving, Dr. Murray said.Alternatively, there’s still time to get fully vaccinated with the one-shot Johnson & Johnson vaccine, but it is not as widely available as the mRNA vaccines, nor is it considered as protective as a two-dose regimen.Think about masks, ventilation and the size of your party.Your family may not have the money to spend on pricey rapid tests. But there are other things you can do to stay protected.Regardless of whether your guests are vaccinated, one of the safest places to gather is outdoors. If you are attending an indoor gathering, open the windows and — if you have the extra cash — consider buying a HEPA air purifier to reduce the amount of airborne virus, Dr. Mina said.The C.D.C. recommends that everyone, including children 2 years old and up, wear a mask if any guests are at increased risk of serious disease, have a weakened immune system or are unvaccinated.If you’re the one hosting Thanksgiving and you have unvaccinated family members, consider limiting your gathering to no more than 10 people and two households, Dr. Salazar suggested. “This is not yet the year where 30 people can gather in one household,” he added.But if everyone in attendance is fully vaccinated and nobody has viral symptoms or any risk factors for serious disease, he advised that gatherings could potentially go up to three family groups or 15 people.“Nothing is foolproof,” he added, including the vaccine.

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In COVID-19 vaccinated people, those with prior infection likely to have more antibodies, research finds

In what is believed to be one of the largest studies of its kind, Johns Hopkins Medicine researchers have shown that antibody levels against SARS-CoV-2 (the COVID-19 virus) stay more durable — that is, remain higher over an extended period of time — in people who were infected by the virus and then received protection from two doses of messenger RNA (mRNA) vaccine compared with those who only got immunized.
A research letter detailing the study of nearly 2,000 health care workers appears today in the Journal of the American Medical Association.
“This finding adds to our understanding of how immunity against SARS-CoV-2 works, and builds upon an earlier study by our team that showed the mRNA vaccines yielded a robust antibody response, even if a person did not develop significant symptoms following vaccination or did not have a prior SARS-CoV-2 infection,” says study senior author Aaron Milstone, M.D., M.H.S., professor of pediatrics at the Johns Hopkins University School of Medicine and pediatric epidemiologist at Johns Hopkins Children’s Center.
The two mRNA vaccines evaluated in the study introduce the body’s immune system to S1, a protein subunit that’s a component of the spikes found on the surface of SARS-CoV-2. The spikes enable the virus to latch onto healthy cells and infect them. Immunoglobulin G antibodies, elicited by S1 from the vaccines stimulating the immune system, neutralize the virus particles, preventing infection by SARS-CoV-2, or at least, reducing the severity of the disease.
For their latest study, the researchers followed 1,960 Johns Hopkins Medicine health care workers who had received both doses of either the Pfizer/BioNTech or Moderna vaccines, including 73 people who had a positive SARS-CoV-2 polymerase chain reaction (PCR) test result before the first vaccine dose. The 73 were divided into two groups — those who were infected at 90 days or closer to the first vaccine dose, and those whose exposure to the virus was more than 90 days before the initial shot.
After adjusting for vaccine type, age and sex, antibody levels were compared for those with and without prior SARS-CoV-2 infection at one, three and six months following the second vaccine dose. In addition, antibody levels were compared at one and three months following the second dose between the two groups with prior SARS-CoV-2 infection.
“We found that health care workers with prior SARS-CoV-2 infection followed by two doses of mRNA vaccine — therefore, three independent exposures to the S1 spike protein — developed higher antibody levels than those with vaccination alone,” says study lead author Diana Zhong, M.D., an infectious diseases fellow at the Johns Hopkins University School of Medicine. “The relative differences were 14% higher at 1 month following the second vaccine dose, 19% at three months and 56% at six months.”
Zhong adds that the study participants with a PCR-confirmed SARS-CoV-2 infection more than 90 days before their initial vaccination had adjusted antibody levels 9% (one month following the second vaccine dose) and 13% (three months following the second vaccine dose) higher than those who were exposed to the virus less than or equal to the 90-day mark.
“This suggests that a longer interval between infection and first vaccine dose may enhance the antibody response,” says Milstone.
Milstone says further investigation is needed to determine whether increased post-vaccination durability in previously infected people is attributable to the number of exposures to the virus, the interval between exposures, or the interplay between natural or vaccine-derived immunity.
The study team at Johns Hopkins Medicine was co-led by Zhong and Shaoming Xiao. Along with them and Milstone, the team includes Amanda Debes, Emily Egbert, Patrizio Caturegli and Elizabeth Colantuoni.
This study was supported by National Institute of Allergy and Infectious Diseases/National Institutes of Health grants T32AI007291 and K24AI141580, along with contributions to the COVID-19 research funds of the Johns Hopkins University School of Medicine and the Johns Hopkins Health System.

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Democrats’ Bill Would Cover Poor Uninsured Adults, Up to a Point

The $1.85 trillion social policy bill would provide free private health insurance for more than two million adults locked out of coverage, but only for four years.ALBANY, Ga. — After giving up on their goal of creating a new Medicaid program to cover two million poor adults, Democrats are aiming to provide them with free private coverage as part of the party’s social policy bill. But there is a catch: The benefits would last only four years.Even with that expiration date, the legislation cannot come fast enough for people like Evelyn Davis, who suffered two heart attacks and has high blood pressure and diabetes. A former home health care aide, she lost coverage when she got divorced two years ago. She has chest pains and heart palpitations but said she cannot afford to see a cardiologist.“If I can’t get any medicine, I just get Tylenol PM when I sleep,” Ms. Davis, 63, said, “and just pray to God when I wake up that I won’t be in pain.”She is among an estimated 2.2 million American adults who lack insurance because they live in one of the 12 states where Republicans have refused to expand Medicaid, which is jointly financed by the federal government and states, under the Affordable Care Act. Too poor to qualify for subsidized private insurance through the Obamacare exchanges yet not poor enough for Medicaid, they navigate a byzantine system of charity care — and often skip care altogether.Now these patients may get what many have hoped for since the Affordable Care Act’s passage more than a decade ago — albeit with no guarantee that the new benefits are here to stay. The framework announced last week by President Biden for the $1.85 trillion social policy bill includes the biggest expansion of health care since the Obama-era health law, patching holes in the landmark law that had long seemed impossible to fix.Still, the framework is tenuous. On Monday, Senator Joe Manchin III, Democrat of West Virginia, dashed hopes for a quick Senate vote by refusing to endorse the measure, whose health care provisions had already been pared back under pressure from Mr. Manchin and other centrists to keep the price down.The “public option,” promoted by Mr. Biden during his presidential campaign as a way for people to buy into a Medicare-like plan, was never even considered. Language authorizing the government to negotiate prices with drug companies was scrapped. A plan to give dental, vision and hearing coverage to Medicare recipients has been whittled down to just hearing.And in the end, negotiators dropped the idea of a new Medicaid plan financed entirely by the federal government for people in the 12 holdout states, which would have been complicated to create, in favor of fully subsidized private coverage — but only through 2025.The free plans would be comparable to Medicaid coverage, with minimal fees for doctor visits and enhanced benefits like transportation to medical appointments. All told, an estimated 4.4 million people — including the uninsured and other low-income adults — would be able to take advantage of them.For Democrats, who took back the House in 2018 and this year gained control of the Senate in part by vowing to expand access to affordable heath care, the bill is a political necessity. And perhaps no Democrat needs it more than Senator Raphael Warnock, Georgia’s first Black senator, who won a special election in January on a promise of expanding Medicaid.Mr. Warnock will be on the ballot again in 2022, a year that is widely expected to be grim for his party, and the contest could determine control of the Senate. In Washington, closing the coverage gap remains Mr. Warnock’s signature issue.“I believe that health care is a human right, and if you believe it’s a human right, you don’t believe it’s a human right for 38 states,” Mr. Warnock said in an interview in September.But some Democrats, notably Mr. Manchin, view solving the problem solely with federal dollars as unfair to states that did expand Medicaid and continue to pay 10 percent of the cost; why, they ask, should Republicans be rewarded for resisting? Republicans oppose the social policy plan in its entirety, calling it a “tax and spending spree.”A rural hospital treating Covid-19 patients in Rio Grande City, Texas. The state accounts for more than a third of people in the Medicaid coverage gap.Christopher Lee for The New York TimesThe profile of those who fall in the gap is much the same as the profile of those hardest hit by the coronavirus pandemic: poor people of color. Most are in the South; Texas alone accounts for more than a third of people in the gap, according to the Kaiser Family Foundation.Della Young, 49, a kidney transplant patient with lupus, was doing fine when she lived in New York. As an end-stage renal disease patient, she is covered by Medicare, which paid 80 percent of her medical expenses. Medicaid picked up the rest.But when Ms. Young moved to McDonough, Ga., in 2015, she lost her Medicaid coverage and was unable to pay for drugs to prevent her body from rejecting her donated organ. Her transplant failed in 2016, and she has been waiting for a new kidney ever since, while undergoing dialysis three times a week. She sends the dialysis center a check for $5 a month — a small offering toward a much larger bill.Because out-of-pocket expenses associated with transplants are so high, Emory Transplant Center, where Ms. Young is a patient, advised her to raise money on her own. She started a GoFundMe account, hoping to raise $100,000. She has raised $5,077 so far.“This whole fund-raising thing is crazy,” she said. “Health care should be the same across the board, regardless of what state you live in.”In Albany, a small city about three hours south of Atlanta, patients like Ms. Davis are eager for any help they can get. She and about a dozen other uninsured people shared their stories in the bare-bones waiting room of the Samaritan Clinic, founded 15 years ago by the Rev. Daniel Simmons, the senior pastor of Mount Zion Baptist Church, who said he had followed the will of God.“People were suffering, dying right in our backyard,” he said. “I said, ‘Lord, what do you want me to do?’”Lisa Jones, 59, lost her employer-sponsored insurance when she gave up her job at a chicken processing plant to care for her ailing husband. He put her on his plan, but when he died she fell into the coverage gap.Nicole Craine for The New York TimesStill, the clinic can only do so much. Lisa Jones, 59, lost her employer-sponsored insurance when she gave up her job at a chicken processing plant to care for her ailing husband. He put her on his plan, but when he died she fell into the coverage gap. She gets blood pressure and cholesterol drugs through the clinic, which works with companies that offer free medicines.But when Ms. Jones sought care for Covid-19, she got a bill for $150. “That went to collections because I didn’t have the money to pay it,” she said.Volunteer doctors provide primary care at the clinic, but Nedra Fortson, a nurse practitioner and the clinic’s executive director, said it was difficult to refer patients to specialists because so many refuse to offer free care. Georgia is one of a dozen states that have not expanded Medicaid under the Affordable Care Act. Addressing the coverage gap has been a priority for the state’s two Democratic senators, Raphael Warnock, center, and Jon Ossoff, right. J. Scott Applewhite/Associated PressSome patients, she said, can afford to go to the community health center, which has a low co-payment of $25. “But oftentimes, once they get in to see a provider and they have to run labs, the patient ends up having a bill,” Ms. Fortson said. “And once they can’t pay that bill, they are unable to get appointments, and so they come to us to get help.”The question of Medicaid expansion has percolated through Georgia politics for much of the past decade. The Affordable Care Act intended for states to expand Medicaid to cover adults with incomes up to 138 percent of the federal poverty line — currently about $17,800 a year for an individual. Republican states sued, and in 2012 the Supreme Court upheld the law but made Medicaid expansion optional.Nedra Fortson, a nurse practitioner and the clinic’s executive director, said it was difficult to refer patients to specialists because so many refuse to offer free care.Nicole Craine for The New York TimesIn 2014, Georgia Republicans went one step further. Fearful that a Democrat would win the governorship, they passed a law requiring the legislature to approve any expansion plan. In 2018, Stacey Abrams, the Democratic candidate for governor, hit Republicans hard on health care. The next year, the state sought to partially expand Medicaid, with requirements for recipients to work.The Trump administration approved the plan, which would have covered only a fraction of the state’s uninsured low-income adults, just days before Mr. Trump lost the 2020 election. The Biden administration, opposed to work requirements, has put it on hold.In the meantime, people in the coverage gap are trying to make do — now with new hope that the social policy bill will become law. Ms. Davis, the former home health care aide, pays $90 out of pocket to see a primary care doctor once a year and gets annual mammograms from the county health department, where they are free. Her children help, but she does not like to accept it.The Democrats’ plan to fully subsidize four years of coverage would tide Ms. Davis over until she turns 65 in two years and becomes eligible for Medicare. She sought Social Security disability benefits, hoping to qualify for Medicare that way, but was unsuccessful.“I filed for disability and they denied me,” she said, “and I’m like, ‘Oh Lord, it ain’t so much about the check.’ If I could just get some insurance so I could see my doctors, that’s all I want.” She added, “If I could get four years, it would be great.”

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How Often Do Covid Vaccines Cause Heart Problems in Kids?

The latest data is reassuring. Myocarditis remains very uncommon, and it is almost always mild and temporary. The heart risk from Covid-19 itself is far greater.Federal regulators are reviewing data on the link between Moderna’s coronavirus vaccine and a rare heart problem in adolescents, the company announced on Sunday. That side effect — myocarditis, an inflammation of the heart muscle — has also worried advisers to federal agencies in deliberations regarding use of the Pfizer-BioNTech vaccine in younger children and teenagers.Scientists advising the Centers for Disease Control and Prevention will review the latest data on the condition at a meeting on Tuesday before deciding whether to recommend the Pfizer-BioNTech vaccine for younger children.So how common is myocarditis, really? And should parents be concerned about vaccinating their children?Absolutely not, said several experts familiar with the recent studies. While the vaccines made by Pfizer-BioNTech and Moderna do seem to be associated with an increased risk of myocarditis, the absolute risk remains very small. Most cases are mild and resolve quickly.“If you look at an isolated risk, you could really get yourself very worked up and scared,” said Dr. Brian Feingold, an expert on heart inflammation in children at UPMC Children’s Hospital of Pittsburgh.But Covid-19 itself, he noted, is much more apt to damage the heart permanently: “Statistically, that’s way more likely.”Myocarditis generally results from infection with a virus or bacteria, and causes symptoms like rapid or irregular heartbeat, chest pain and shortness of breath. Globally, about 10 to 20 people out of every 100,000 develop myocarditis each year, but many others have mild symptoms and may never be diagnosed.Since the start of the coronavirus pandemic, tens of thousands of children have been hospitalized with Covid, and 657 have died, according to data collected by the C.D.C.Some children who are infected with the coronavirus may go on to develop long Covid, remaining ill for months after the initial infection is gone, or multisystem inflammatory syndrome, which has affected at least 5,200 children in the United States.While the risk of myocarditis after vaccination is real, “those are real numbers that are bigger,” Dr. Feingold said.The incidence of myocarditis after vaccination varies with age, sex and dose — and across studies. But the trend so far suggests that the chances are highest after the second dose of an mRNA vaccine in male patients age 16 to 29.There are roughly 11 cases of myocarditis for every 100,000 vaccinated male patients in this age group, one study estimated. The odds of myocarditis decrease with age.Data on adolescents age 12 to 15 years is limited, because the Pfizer-BioNTech vaccine only recently became available to them. But so far, heart problems after vaccination seem to be less common in boys of that age than in older men, said Dr. Paul A. Offit, director of the Vaccine Education Center at Children’s Hospital of Philadelphia.This age distribution is similar to that seen among patients with myocarditis caused by viral infections, Dr. Offit said.An F.D.A. scientific advisory committee, on which he sits, met last week to review the Pfizer-BioNTech vaccine’s safety in children 5 through 11 and ultimately voted to recommend that children be given the vaccine.“Myocarditis is usually a post-pubertal phenomenon,” Dr. Offit said, adding, “That made me feel better about the fact that we won’t be unpleasantly surprised” by a surge in myocarditis in younger children after they are immunized.It’s unclear why myocarditis seems to affect boys more often than girls, and whether it is specific to the coronavirus vaccines or a side effect of all mRNA vaccines.Matt Slocum/Associated PressThat reassurance may not be enough for some parents. Jeff Gustin, a plant geneticist at the Agriculture Department, said he and two of his sons had elevated heart rates after getting the Pfizer-BioNTech vaccine.His teenage sons recovered quickly, but Dr. Gustin, 42, says he can still feel his heart beating hard, especially when he lies down. Now he is considering a booster of the Johnson & Johnson vaccine, rather than of the Pfizer-BioNTech or Moderna vaccine.And given the family history, he is hesitant to have his youngest son, who is 11, immunized unless the school district requires it.But some instances of myocarditis after immunization, like those of Dr. Gustin’s older sons, may be detected simply because of the intense scrutiny on vaccines, said Dr. James de Lemos, a cardiologist at the University of Texas Southwestern Medical Center in Dallas, who reported one of the first cases in January..css-1kpebx{margin:0 auto;font-family:nyt-franklin,helvetica,arial,sans-serif;font-weight:700;font-size:1.125rem;line-height:1.3125rem;color:#121212;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-family:nyt-cheltenham,georgia,’times new roman’,times,serif;font-weight:700;font-size:1.375rem;line-height:1.625rem;}@media (min-width:740px){#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-size:1.6875rem;line-height:1.875rem;}}@media (min-width:740px){.css-1kpebx{font-size:1.25rem;line-height:1.4375rem;}}.css-1gtxqqv{margin-bottom:0;}.css-k59gj9{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-flex-direction:column;-ms-flex-direction:column;flex-direction:column;width:100%;}.css-1e2usoh{font-family:inherit;display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-webkit-justify-content:space-between;-ms-flex-pack:justify;justify-content:space-between;border-top:1px solid #ccc;padding:10px 0px 10px 0px;background-color:#fff;}.css-1jz6h6z{font-family:inherit;font-weight:bold;font-size:1rem;line-height:1.5rem;text-align:left;}.css-1t412wb{box-sizing:border-box;margin:8px 15px 0px 15px;cursor:pointer;}.css-hhzar2{-webkit-transition:-webkit-transform ease 0.5s;-webkit-transition:transform ease 0.5s;transition:transform ease 0.5s;}.css-t54hv4{-webkit-transform:rotate(180deg);-ms-transform:rotate(180deg);transform:rotate(180deg);}.css-1r2j9qz{-webkit-transform:rotate(0deg);-ms-transform:rotate(0deg);transform:rotate(0deg);}.css-e1ipqs{font-size:1rem;line-height:1.5rem;padding:0px 30px 0px 0px;}.css-e1ipqs a{color:#326891;-webkit-text-decoration:underline;text-decoration:underline;}.css-e1ipqs a:hover{-webkit-text-decoration:none;text-decoration:none;}.css-1o76pdf{visibility:show;height:100%;padding-bottom:20px;}.css-1sw9s96{visibility:hidden;height:0px;}.css-1in8jot{background-color:white;border:1px solid #e2e2e2;width:calc(100% – 40px);max-width:600px;margin:1.5rem auto 1.9rem;padding:15px;box-sizing:border-box;font-family:’nyt-franklin’,arial,helvetica,sans-serif;text-align:left;}@media (min-width:740px){.css-1in8jot{padding:20px;width:100%;}}.css-1in8jot:focus{outline:1px solid #e2e2e2;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1in8jot{border:none;padding:10px 0 0;border-top:2px solid #121212;}What to Know About Covid-19 Booster ShotsThe F.D.A. has authorized booster shots for millions of recipients of the Pfizer-BioNTech, Moderna and Johnson & Johnson vaccines. Pfizer and Moderna recipients who are eligible for a booster include people 65 and older, and younger adults at high risk of severe Covid-19 because of medical conditions or where they work. Eligible Pfizer and Moderna recipients can get a booster at least six months after their second dose. All Johnson & Johnson recipients will be eligible for a second shot at least two months after the first.Yes. The F.D.A. has updated its authorizations to allow medical providers to boost people with a different vaccine than the one they initially received, a strategy known as “mix and match.” Whether you received Moderna, Johnson & Johnson or Pfizer-BioNTech, you may receive a booster of any other vaccine. Regulators have not recommended any one vaccine over another as a booster. They have also remained silent on whether it is preferable to stick with the same vaccine when possible.The C.D.C. has said the conditions that qualify a person for a booster shot include: hypertension and heart disease; diabetes or obesity; cancer or blood disorders; weakened immune system; chronic lung, kidney or liver disease; dementia and certain disabilities. Pregnant women and current and former smokers are also eligible.The F.D.A. authorized boosters for workers whose jobs put them at high risk of exposure to potentially infectious people. The C.D.C. says that group includes: emergency medical workers; education workers; food and agriculture workers; manufacturing workers; corrections workers; U.S. Postal Service workers; public transit workers; grocery store workers.Yes. The C.D.C. says the Covid vaccine may be administered without regard to the timing of other vaccines, and many pharmacy sites are allowing people to schedule a flu shot at the same time as a booster dose.The myocarditis linked to the vaccines is far less frequent and severe compared with that observed in patients with Covid, and it does not seem to cause lasting harm, Dr. de Lemos said.The coronavirus can infect cardiac muscle, as well as the lining of blood vessels, putting the heart and other organs at risk of long-term damage. The virus can also weaken the heart enough to require a transplant, and even cause lethal damage.By contrast, the myocarditis observed after vaccination is mild and transient. “It’s unsettling, but rarely life-threatening,” Dr. de Lemos said.Still, some Northern European countries, where the Moderna vaccine was already approved for adolescents, have stopped giving it to people age 30 and younger, at least for the moment. That decision was based on evidence suggesting that the risk of myocarditis is higher with the Moderna vaccine than with the Pfizer-BioNTech vaccine.When researchers at Kaiser Permanente Northern California directly compared the two vaccines, for example, they found that in men 18 to 39 the incidence of myocarditis was elevated after a dose of either vaccine, but more so after Moderna’s.“The rate after Moderna is objectively higher than the rate after Pfizer,” said Dr. Nicola P. Klein, director of the Kaiser Permanente Vaccine Study Center. “It’s consistent, regardless of which cases we use, or whether it’s males only or both sexes.”The risk after both doses of the Moderna vaccine in people age 18 to 39 was as much as 37 times as high as in the general population, and the rate after two doses of the Pfizer-BioNTech vaccine in those age 12 to 39 was as much as 19 times as high.While that may sound alarming, the absolute numbers were still tiny, Dr. de Lemos noted. “Thirty times a small number is still a small number,” he said. “The math still favors vaccination in adolescents and children.”It’s unclear why myocarditis seems to affect boys more often than girls, and whether it is specific to the coronavirus vaccines or a side effect of all mRNA vaccines. The focus on myocarditis after vaccination may also help to understand the condition generally, experts said.“I’ll feel a lot better about this when we have an understanding of the pathogenesis, of exactly what is it that’s going on,” Dr. Offit said. If doctors can identify the cause, he added, “we may be able to treat it to some extent.”

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