Blood markers of brain cell damage higher over short term in COVID-19 patients than in Alzheimer's patients, study finds
Patients hospitalized for COVID-19 had higher levels over the short term of blood proteins known to rise with neurological damage than non-COVID-19 patients diagnosed with Alzheimer’s disease, a new study finds.
Importantly, the current report, published online January 13 in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, was conducted over two months early in the pandemic (March-May 2020). Any determination of whether patients with COVID-19 are at increased risk for future Alzheimer’s disease, or instead recover over time, must await the outcomes of long-term studies.
Led by researchers at NYU Grossman School of Medicine, the new study found higher levels of seven markers of brain damage (neurodegeneration) in COVID-19 patients with neurological symptoms than those without them, and much higher levels in patients that died in the hospital than in those discharged and sent home.
A second analysis found that a subset of the damage markers in patients hospitalized with COVID-19, over the short term were significantly higher than in patients diagnosed with Alzheimer’s disease, and in one case more than twice as high.
“Our findings suggest that patients hospitalized for COVID-19, and especially in those experiencing neurological symptoms during their acute infection, may have levels of brain injury markers that are as high as, or higher than, those seen in patients with Alzheimer’s disease,” says lead author Jennifer A. Frontera, MD, professor in the Department of Neurology at NYU Langone Health.
Study Structure/Details
The current study identified 251 patients that, although 71 years on age on average, had no record or symptoms of cognitive decline or dementia before being hospitalized for COVID-19. These patients were then divided into groups with and without neurological symptoms during their acute COVID-19 infection, when patients either recovered and were discharged, or died.








