Ed Davey ‘minded’ to vote against assisted dying bill
PA MediaLib Dem leader Sir Ed Davey has said he is “minded” to vote against an upcoming bill to legalise assisted dying.
Read more →PA MediaLib Dem leader Sir Ed Davey has said he is “minded” to vote against an upcoming bill to legalise assisted dying.
Read more →It would be “crazy” to leave breast tissue behind during a mastectomy, a disgraced breast surgeon has told an inquest into the death of one of his patients.
Read more →Getty ImagesThe Liberal Democrats have called on the government to exempt social care from the rise in National Insurance.
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In 2021, NIH launched the Researching COVID to Enhance Recovery (RECOVER) Initiative, a nationwide research program, to fully understand, diagnose, and treat Long COVID. We continue to learn more about this condition, in which some people experience a variety of symptoms for weeks, months, or even years after infection with SARS-CoV-2, the virus that causes COVID-19. But we’re still working to understand the underlying reasons why people develop Long COVID, who is most likely to get it, and how best to treat or prevent it.
Studies have shown that for some people, SARS-CoV-2 doesn’t completely clear out after acute infection. Scientists have observed signs that the virus may persist in various parts of the body, and many suspect that this lingering virus, or remnants consisting of SARS-CoV-2 protein, may be causing Long COVID symptoms in some individuals. Now, in a new study supported by RECOVER, scientists found that people with Long COVID were twice as likely to have these viral remnants in their blood as people with no lingering symptoms. The findings, reported in Clinical Microbiology and Infection, add to evidence that Long COVID may sometimes stem from persistent infection or SARS-CoV-2 protein remnants.
The study team, led by David Walt and Zoe Swank at Brigham and Women’s Hospital in Boston, had earlier found preliminary evidence in a small pilot study that a SARS-CoV-2 protein could often be detected in the bloodstreams of people with Long COVID up to a year after the initial infection. In the new study, they wanted to better quantify this in a much larger group of people with Long COVID. The researchers developed a highly sensitive test to look for whole and partial proteins from the SARS-CoV-2 virus. They analyzed 1,569 blood samples collected from 706 people at various times after SARS-CoV-2 infection.
Overall, 21% of those in the study had detectable levels of a SARS-CoV-2 protein between 4 and 7 months after infection. In total, 82% of the study’s participants (578 people) had at least one symptom of Long COVID more than a month after their infections. Commonly reported symptoms included fatigue, brain fog, muscle pain, joint pain, back pain, headache, sleep disturbance, loss of smell or taste, and gastrointestinal symptoms. More than half of participants in this group (378 people) reported experiencing ongoing cardiopulmonary, musculoskeletal, or neurologic symptoms, and among those participants, 43% (165 people) had detectable virus protein. Also of note, of the asymptomatic people, about 20% had detectable virus protein.
While the researchers can’t definitively show that persistent infections are the cause of some Long COVID symptoms, the findings add to growing evidence that low levels of viral protein being present may explain some but not all cases of Long COVID. The authors and many other researchers suspect that Long COVID likely has multiple underlying causes. For instance, it’s possible that the virus may lead to harmful changes in the immune system that play a role in some cases of Long COVID.
Scientists also want to see if there is a subset of people with Long COVID or persistent symptoms who may benefit from antiviral treatment. To this end, RECOVER is supporting a clinical trial evaluating whether the antiviral drug Paxlovid (a combination of nirmatrelvir and ritonavir), which is used to treat COVID-19, could also be used to improve Long COVID symptoms. The trial is using the SARS-CoV-2 blood test developed by the Brigham and Women’s study team to evaluate whether Paxlovid can eliminate viral proteins from participants’ blood.
More study is needed to understand the causes of Long COVID symptoms in people who test negative for persistent infection, the researchers note. They are conducting follow-up studies in even more people with Long COVID, including those with compromised immune systems. They hope to learn more about what causes some people to be at higher risk for retaining some SARS-CoV-2 protein remnants and Long COVID.
Reference:
Swank Z, et al; RECOVER consortium authors. Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study. Clinical Microbiology and Infection. DOI: 10.1016/j.cmi.2024.09.001 (2024).
NIH Support: RECOVER Initiative; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute
Read more →PA MediaA leading midwife who has led reviews into care failings in the NHS has criticised the health service for “failing” to give her daughter safe care.
Read more →As libraries become public stages for social problems — homelessness, drug use, mental health — the people who work there are burning out.On social media, Mychal Threets was spreading the gospel of “library joy” to hundreds of thousands of followers.Known for his energetic delivery and signature Afro, Mr. Threets showed off the book-themed tattoos covering his arms and evangelized about the pleasure of reading while cradling one of his cats. Viewers found his enthusiasm for literature infectious, and he got a kick out of drawing in young readers.But at his job, as a supervisor at the Fairfield Civic Center Library in Solano County, Calif., he was facing new challenges. The library, which he had begun visiting as a child, had become a gathering place for people experiencing issues like homelessness, drug dependence and mental illness.Some of his duties had little to do with cataloging books and recommending titles. Over a year, Mr. Threets said, he filed more than 170 incident reports documenting how library patrons had acted out: property damage, harassment, physical altercations.“There were several instances where people would get in my face and kind of threaten to physically push me,” Mr. Threets said. At one point, he added, a patron threatened to kill him multiple times — visitors pulled knives on each other, too.His anxiety and depression, both present since childhood, had worsened. And he faced an impossible dilemma: What do you do when the pressures of your profession are harming your mental health?We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.
Read more →Breaking up the C.D.C., moving funds from the N.I.H. — conservatives have floated changes should Mr. Trump regain office.The Covid pandemic dominated the last years of Donald Trump’s presidency, and the discontent it caused most likely contributed to his loss in 2020. But on the campaign trail this year, Mr. Trump rarely talks in depth about public health, dwelling instead on immigration, the economy and his grievances.Still, Project 2025, the blueprint for a new Republican administration shaped by many former Trump staff members, lays out momentous changes to the Food and Drug Administration, the Centers for Disease Control and Prevention, and the National Institutes of Health.And Mr. Trump’s embrace of Robert F. Kennedy Jr., a vaccine skeptic, and his campaign slogan, “Make America Healthy Again,” suggests there will be significant changes to the nation’s public health priorities should Mr. Trump regain the presidency.“I’m going to let him go wild on health,” Mr. Trump said of Mr. Kennedy at a rally in New York City on Sunday. “I’m going to let him go wild on the food. I’m going to let him go wild on medicines.”Republican critics increasingly describe the health agencies as corrupt, riddled with conflicts of interest and staffed by myopic bureaucrats accountable to no one.Mr. Trump echoed these themes at a rally in Wisconsin: “We’ll take on the corruption at the F.D.A., the C.D.C., World Health Organization and other institutions of public health that have dominated, and really are dominated by corporate power, and dominated really by China.”We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.
Read more →When I arrive at an abortion clinic in south London, four protesters – three women and one man – are gathered on the opposite side of the road alongside a picture of the Virgin Mary, which is draped in rosary beads. They are silently mouthing prayers, and ask not to be interrupted.
Read more →A large trial showed that semaglutide, sold as Ozempic for diabetes and as Wegovy for obesity, was better than any current medications in alleviating symptoms.The blockbuster drug semaglutide, sold as Ozempic for diabetes and as Wegovy for weight loss, now has a new proven benefit: It markedly soothed knee pain in people who are obese and have moderate to severe osteoarthritis, according to a large study.The effect was so pronounced that some arthritis experts not involved with the clinical trial were taken aback.“The magnitude of the improvement is of a scope we haven’t seen before with a drug,” said Dr. Bob Carter, deputy director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases. “They had an almost 50 percent reduction in their knee pain. That’s huge.”Dr. David T. Felson, an arthritis expert and professor of medicine at Boston University School of Medicine, said the study “changes the landscape,” adding that the pain reduction is greater than anything that can be achieved short of knee replacement surgery.The results were published Wednesday in the New England Journal of Medicine.Knee osteoarthritis affects nearly one in five Americans over the age of 45. Those with obesity are especially likely to develop it because their weight puts more stress on the knee and because obesity is associated with inflammation, which contributes to deterioration of cartilage.There are no good medical treatments. Doctors can suggest patients take over-the-counter pain relievers like acetaminophen or ibuprofen. But long-term use of those medications can damage vital organs.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.
Read more →Donald Trump and other Republicans have said repeatedly that she does. Her history on the issue is complicated.One of former president Donald J. Trump’s final television ads before Election Day reprises an old talking point.The segment, released Oct. 17, declares that Vice President Kamala Harris “wants struggling seniors to pay more Social Security taxes while she gives Medicare and Social Security to illegals.”The first half of the statement is inaccurate. Ms. Harris has not suggested raising Social Security taxes for seniors; instead, she has said she supports eliminating the $168,000 income cap on the taxes workers pay to fund Social Security, a threshold above which income becomes exempt. Under that proposal, Social Security taxes would increase for working people who earn almost three times median annual pay, not for struggling seniors.The latter half of the ad’s claim — that Ms. Harris supports giving taxpayer-funded health benefits to illegal immigrants — is a misrepresentation of Ms. Harris’s current proposals. Ms. Harris made statements in 2019 that could be understood this way, but she has stepped back from that position in recent months as her health care platform has become clearer. Mr. Trump has also misstated the Biden administration’s policy. Here is a look at what that is and what Ms. Harris has said about the issue.What is the current federal policy?Immigrants who live in the United States illegally do not qualify for federally funded coverage through Medicare, Medicaid or the Children’s Health Insurance Program, which provides health coverage for low-income children. In most states, they are also ineligible to buy private health coverage through the Affordable Care Act marketplaces.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.
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