Can Long-Term Care Employers Require Staff Members to Be Vaccinated?

#masthead-section-label, #masthead-bar-one { display: none }The Coronavirus OutbreakliveLatest UpdatesMaps and CasesRisk Near YouVaccine RolloutNew Variants TrackerAdvertisementContinue reading the main storySupported byContinue reading the main storythe new old ageCan Long-Term Care Employers Require Staff Members to Be Vaccinated?As legal experts and ethicists debate, some companies aren’t waiting.Joe Pendergast, a resident of Juniper Village, a nursing home in Bensalem, Pa., with Kevin Birtwell, a wellness nurse manager there. All staff members at Juniper are required to be vaccinated.Credit…Kriston Jae Bethel for The New York TimesMarch 5, 2021, 5:00 a.m. ETFor much of the winter, Meryl Gordon worried about the people caring for her 95-year-old mother, who was rehabbing in a Manhattan nursing home after surgery for a broken hip.“Every week they sent out a note to families about how many staff members had positive Covid tests,” said Ms. Gordon, a biographer and professor at New York University. “It was a source of tremendous anxiety.”Ms. Gordon feels reassured now that her mother is fully vaccinated and has returned to her assisted living facility. But what about the two home care aides who help her 98-year-old father, David, in his Upper West Side apartment?Neither has agreed to be vaccinated. David Gordon’s doctor has advised him to delay Covid vaccination himself because of his past allergic reactions.Ms. Gordon has not insisted that the caregivers receive vaccinations. “You’re reluctant to do something that could cause you to lose the people you rely on,” she said. But she remains uneasy.It’s a question that many long-term care employers, from individual families to big national companies, are confronting as vaccines become more available, although not available enough: In a pandemic, can they require vaccination for those who care for very vulnerable older adults? Should they?Some employers aren’t waiting. Atria Senior Living, one of the nation’s largest assisted living chains, has announced that by May 1 all staff members must be fully vaccinated.Silverado, a small chain of dementia care homes, most on the West Coast, mandated vaccination by March 1. Juniper Communities, which operates 22 facilities in four states, has also adopted a mandate.“We felt it was the best way to protect people, not just our residents but our team members and their families,” said Lynne Katzmann, Juniper’s chief executive. Of the company’s nearly 1,300 employees, “about 30 individuals have self-terminated” because of the vaccination requirement, she reported.Juniper’s experience supports what public health experts have said for years: Vaccine mandates, like those that many health care organizations have established for the flu vaccine, remain controversial — but they do increase vaccination rates. As of Feb. 25, 97.7 percent of Juniper residents had received two vaccine doses, and so had 96 percent of its staff members.Tamara Moreland, executive director at Juniper Village in Bensalem. The company operates 22 facilities in four states and reports about 30 “self-terminations” of its nearly 1,300 employees.Credit…Kriston Jae Bethel for The New York TimesThat stands in stark contrast to staff vaccinations in many facilities. The Centers for Disease Control and Prevention has reported that during the first month of vaccine clinics in nursing homes, only 37.5 percent of staff members received the first shot, along with 77.8 percent of residents.The results of opinion surveys vary, depending on who is asked and when. In January, a Kaiser Family Foundation analysis found that 29 percent of health care workers expressed doubts about vaccination.A national recruiting platform for health care companies, myCNAjobs.com, last month polled 250 companions, aides and nursing assistants in facilities and in home care; it interviews thousands more daily. It estimates that 35 percent plan to be vaccinated, 20 percent do not and more than 40 percent remain unsure.The Coronavirus Outbreak

Read more →

Weekly Health Quiz: Covid Vaccines, Side Effects and Exercise

.layout-medium .main{max-width:none}@media screen and (max-device-width:767px),screen and (max-width:767px){.main{margin:0;padding:0}}.ad.top-ad{overflow:hidden;width:100%;max-width:100%;margin-left:0;margin-right:0}.lede-container-ads{display:none;position:relative}.bottom-container-ads{text-align:center}.sharetools-story{display:none}.page-interactive-app .story-header{padding:0 16px}.comments-button.theme-kicker{display:none}#sharetools-interactive{top:-6px}.viewport-small-10 #sharetools-interactive{top:0}.story.theme-main .story-header .story-meta .story-heading{line-height:1}.page-interactive .story.theme-main .story-header{border:0;margin:0 auto;padding:0 16px}.page-interactive .story.theme-main .story-header .story-meta{margin-bottom:0}.page-interactive .story.theme-main .story-header .story-meta .kicker-container{margin-bottom:10px}.page-interactive .story.theme-main .story-header .story-meta .kicker-container #sharetools-interactive{left:auto;right:16px;bottom:auto;display:block}.page-interactive .story.theme-main .story-header .story-meta .story-heading{font-family:nyt-cheltenham,georgia,times new roman,times,serif;font-size:42px;line-height:1.1;margin:0 auto;text-align:left}.page-interactive .story.theme-main .story-header .story-meta .story-meta-footer .summary{font-family:nyt-cheltenham,georgia,times new roman,times,serif;font-size:18px;font-weight:100;margin-top:15px;margin-bottom:0;line-height:1.3;color:#666}.page-interactive .story.theme-main .story-header:after{content:””;display:block;background:#e2e2e2;height:1px;width:auto;margin-top:32px}.video_container .nytd-player-container{margin-bottom:7px}.media.photo[data-media-action=modal]{pointer-events:none}.media-viewer-asset img{width:100%;display:block}.leadin-body{border-bottom:1px solid #ccc;padding:0 16px 20px}.marginalia{display:none;border-top:1px dotted #999;width:300px;float:right;clear:right;margin:5px 0 45px 30px;padding-top:10px}.marginalia .module-heading{font-size:11px;font-size:.6875rem;line-height:11px;line-height:.6875rem;font-weight:700;font-family:nyt-franklin,arial,helvetica,sans-serif;color:#000;text-transform:uppercase;margin-bottom:1em}.marginalia ul{margin:0}.marginalia ul li{margin-bottom:.75em}.marginalia ul li:last-child{margin-bottom:0}.marginalia .story .story-link{text-decoration:none}.story.theme-summary .thumb{float:left;clear:left;margin:0 10px 0 0;width:75px;height:75px}.marginalia .story .thumb{position:relative;max-width:65px;width:21.67%;height:auto;clear:none;margin-left:0}.marginalia .story .thumb img{height:auto;width:auto}.marginalia .story .story-heading{color:#333;font-size:13px;font-size:.8125rem;line-height:17px;line-height:1.0625rem;font-weight:400;font-family:nyt-cheltenham-sh,georgia,times new roman,times,serif}.marginalia .story .thumb+.story-heading{float:left;clear:left;margin:0;width:74.5%;clear:right}.marginalia .story .story-heading .story-heading-text{padding-right:.75em}.marginalia .story .story-link .story-heading-text,.marginalia .story .story-link:hover{color:#326891}.marginalia .story .story-link:active .story-heading-text,.marginalia .story .story-link:hover .story-heading-text{text-decoration:underline}.related-coverage-marginalia{top:100%;position:absolute;right:0}.related-coverage,.story.theme-main .story-footer{padding:0 16px}.page-interactive .story.theme-main .story-header .story-meta .story-heading{font-size:41px;line-height:.97560975609756;text-align:center;font-weight:200}.page-interactive .story.theme-main .story-header .story-meta .story-heading:after{content:””;display:block;width:180px;height:1px;border-bottom:1px solid #ccc;margin:20px auto 10px}.page-interactive .story.theme-main .story-header .story-meta .story-meta-footer .summary{font-family:nyt-franklin,Arial,helvetica,sans-serif;font-size:14px;line-height:1.42857142857143;font-weight:500;color:#3f3f3f}.story.theme-main .dateline{font-family:nyt-franklin,Arial,helvetica,sans-serif;font-size:14px;line-height:1.42857142857143;font-weight:500;color:#7f7f7f}.viewport-medium-10 .story.theme-main .story-header{padding:0}.viewport-medium-10 #sharetools-interactive{display:block}.viewport-medium-10 .story.theme-main .sharetools-story{clear:left;display:block;float:left;position:relative;width:65px}.viewport-medium-10 .story.theme-main .sharetools-story >ul{position:absolute}.viewport-medium-10 .story.theme-main .sharetools.sharetools-story .sharetool.show-all-sharetool{margin-left:0}.viewport-medium-10 .comments-button.theme-kicker{display:inline-block}.viewport-medium-10 .story.theme-main .story-header{margin-top:16px;max-width:auto}.viewport-medium-10 .story.theme-main .story-header .story-meta{margin-bottom:10px}.viewport-medium-10 .story.theme-main .story-header .story-meta .story-heading{font-size:60px;text-align:center}.viewport-medium-10 .story.theme-main .story-header .story-meta .story-meta-footer .byline-dateline{text-align:center}.viewport-medium-10 .story.theme-main .story-header .story-meta .story-meta-footer .summary{text-align:center;margin-left:auto;margin-right:auto;margin-top:20px;max-width:720px;font-size:20px}.viewport-medium-10 .story.theme-main .story-header:after{margin-top:48px}.viewport-medium-10 .leadin-body{margin-bottom:16px;margin-left:105px;padding:0 0 32px;width:510px}.viewport-medium-10 .media.photo[data-media-action=modal]{pointer-events:auto}.viewport-medium-10 .marginalia{margin-top:720px}.viewport-medium-10 .related-coverage,.viewport-medium-10 .story.theme-main .story-footer{padding:0}.viewport-medium-10 .bottom-container-ads{display:none}.viewport-medium-10 .lede-container-ads{clear:right;display:none;float:right;position:relative}.viewport-medium-10 .lede-container-ads .ad{position:absolute;margin:0 0 40px 7px;top:0;right:0}.viewport-large .story.theme-main .story-header{max-width:1020px;margin:0 auto}.viewport-large .story.theme-main .story-header .story-meta .story-heading{max-width:80%;font-weight:200}.fade{opacity:0;transition:opacity .8s}.fade.faded{opacity:1}.fill-in-blank{display:inline-block;border-bottom:1px solid #000;width:100px}.cascade,.one-at-a-time,.quiz{margin-top:30px}.cascade .media img,.one-at-a-time .media img,.quiz .media img{width:100%;display:block}.cascade h2,.one-at-a-time h2,.quiz h2{font-size:24px;margin-top:2em;margin-bottom:1em}.cascade p,.one-at-a-time p,.quiz p{font-size:16px;line-height:1.4;font-weight:400;font-style:normal;font-family:georgia,times new roman,times,serif}@media only screen and (min-width:480px){.cascade p,.one-at-a-time p,.quiz p{font-size:17px;line-height:1.625rem}}.cascade >.media,.cascade >.video,.one-at-a-time >.media,.one-at-a-time >.video,.quiz >.media,.quiz >.video{margin-bottom:45px;width:100%;max-width:1020px;margin-left:auto;margin-right:auto}@media only screen and (min-width:480px){.cascade .conclusion,.cascade .response,.cascade >.text-block,.one-at-a-time .conclusion,.one-at-a-time .response,.one-at-a-time >.text-block,.quiz .conclusion,.quiz .response,.quiz >.text-block{max-width:600px;margin-left:auto;margin-right:auto;box-sizing:border-box}}.cascade .response,.one-at-a-time .response,.quiz .response{margin-top:2em}.cascade .conclusion >.text-block p:first-of-type,.one-at-a-time .conclusion >.text-block p:first-of-type,.quiz .conclusion >.text-block p:first-of-type{margin-top:1em}.done-button{display:block;text-align:center}.done-button >.text-block{display:inline-block;background-color:#fff;padding:10px 15px;border:1px solid #053e69;border-radius:3px;cursor:pointer;margin-top:10px;transition:all .35s ease-out;transition-property:padding,background-color}.done-button >.text-block p{margin-top:0;margin-bottom:0}.reset-block{margin-top:20px}.cascade >.reset-block,.one-at-a-time >.reset-block,.quiz >.reset-block{text-align:center}.clear-saved{font-family:nyt-franklin,Arial,helvetica,sans-serif;font-size:15px;line-height:1.5;cursor:pointer;background:#053e69;display:inline-block;border-radius:4px;padding:8px 20px;color:#fff}.clear-saved,.clear-saved:hover{text-decoration:none}.clear-saved p{margin-bottom:0}@media only screen and (min-width:480px){.reset-block{margin-top:50px}}.video .credit{font-size:14px}@media only screen and (min-width:480px){.step{max-width:600px;margin-left:auto;margin-right:auto;box-sizing:border-box}}.multiple-choice-question,.multiple-select-question{position:relative;border-bottom:1px solid #ccc;padding-top:23px;padding-bottom:34px}@media only screen and (min-width:480px){.multiple-choice-question,.multiple-select-question{padding-top:47px;padding-bottom:39px}}.multiple-choice-question p,.multiple-select-question p{font-size:16px;line-height:1.4;font-weight:400;font-style:normal;font-family:georgia,times new roman,times,serif;font-size:18px;line-height:1.625rem}@media only screen and (min-width:480px){.multiple-choice-question p,.multiple-select-question p{font-size:17px;line-height:1.625rem;font-size:20px;line-height:1.5}}.multiple-choice-question .counter,.multiple-select-question .counter{font-size:16px;line-height:1.4;font-weight:400;font-style:normal;font-family:georgia,times new roman,times,serif;font-size:20px;line-height:1.5;color:#656565;margin-bottom:12px}@media only screen and (min-width:480px){.multiple-choice-question .counter,.multiple-select-question .counter{font-size:17px;line-height:1.625rem}}.multiple-choice-question .media,.multiple-select-question .media{margin-bottom:14px}.multiple-choice-question .media img,.multiple-select-question .media img{width:100%}.multiple-choice-question .response,.multiple-select-question .response{border-left:1px solid rgba(0,0,0,.05);padding-left:19px}.multiple-choice-question .response p,.multiple-select-question .response p{font-size:16px;line-height:1.4;font-weight:400;font-style:normal;font-family:georgia,times new roman,times,serif;color:#777}@media only screen and (min-width:480px){.multiple-choice-question .response p,.multiple-select-question .response p{font-size:17px;line-height:1.625rem}}.multiple-choice-question .done-button,.multiple-select-question .done-button{text-align:center}.multiple-choice-question .done-button.is-complete,.multiple-select-question .done-button.is-complete{display:none}.multiple-choice-question.answering .done-button,.multiple-select-question.answering .done-button{display:block}.multiple-choice-question .answer,.multiple-select-question .answer{display:block;position:relative;padding:15px 20px;border-radius:3px;margin-top:10px;cursor:pointer;background:#eaf2f9;line-height:1.25;color:#053e69;transition:all .35s ease-out;transition-property:padding,background-color}.multiple-choice-question .answer p,.multiple-select-question .answer p{margin-top:0;margin-bottom:0}.multiple-choice-question.answered .answer,.multiple-select-question.answered .answer{color:#656565;cursor:default;background-color:#f7f7f7}.multiple-choice-question.answered .answer.selected,.multiple-select-question.answered .answer.selected{background-color:#9b9078;color:#fff}.multiple-choice-question.unanswered .answer.selected,.multiple-select-question.unanswered .answer.selected{background-color:#053e69;color:#fff}.multiple-choice-question.has-correct-answers .answer,.multiple-select-question.has-correct-answers .answer{background-size:19px 19px;background-position:calc(100% – 20px) 20px;background-repeat:no-repeat}.multiple-choice-question.answered.has-correct-answers .answer.selected,.multiple-select-question.answered.has-correct-answers .answer.selected{background-image:url(https://static01.nyt.com/inc/quiz-x_light.svg);background-color:#e27676;color:#fff}.multiple-choice-question.answered.has-correct-answers .answer.correct,.multiple-select-question.answered.has-correct-answers .answer.correct{background-image:url(https://int.nyt.com/assets/adventure/images/quiz-check_green.svg);color:#97c19a}.multiple-choice-question.answered.has-correct-answers .answer.selected.correct,.multiple-select-question.answered.has-correct-answers .answer.selected.correct{background-color:#95c198;background-image:url(https://static01.nyt.com/inc/quiz-check_light.svg);color:#fff}.multiple-choice-question .poll-answer,.multiple-choice-question .poll-answer p,.multiple-select-question .poll-answer,.multiple-select-question .poll-answer p{font-family:Arial,Helvetica,sans-serif}.multiple-choice-question .poll-answer-percentage,.multiple-select-question .poll-answer-percentage{float:right;font-size:16px;font-size:20px;line-height:1.5;font-weight:400;color:#bfbfbf}.multiple-choice-question .poll-answer-graph,.multiple-select-question .poll-answer-graph{position:absolute;left:0;top:1px;z-index:-1;height:calc(100% – 4px);background-color:#f2f2f2;transition:width .5s ease-in-out}.multiple-choice-question.unanswered .poll-answer-graph,.multiple-select-question.unanswered .poll-answer-graph{width:0!important}.multiple-choice-question.unanswered .poll-answer-percentage,.multiple-select-question.unanswered .poll-answer-percentage{display:none}.multiple-choice-question.answered .poll-answer,.multiple-select-question.answered .poll-answer{background-color:transparent}.multiple-choice-question.answered.has-correct-answers .poll-answer,.multiple-select-question.answered.has-correct-answers .poll-answer{color:#656565;padding-right:50px}.multiple-choice-question.answered.has-correct-answers .poll-answer.selected,.multiple-select-question.answered.has-correct-answers .poll-answer.selected{color:#f47851;background-color:transparent;background-image:url(https://static01.nyt.com/inc/quiz-x_red.svg)}.multiple-choice-question.answered.has-correct-answers .poll-answer.selected.correct,.multiple-select-question.answered.has-correct-answers .poll-answer.selected.correct{color:#f47851;background-color:transparent;background-image:url(https://int.nyt.com/assets/adventure/images/quiz-check_green.svg)}.multiple-choice-question.answered .answer.selected,.multiple-select-question.answered .answer.selected{background-color:transparent;color:#656565}.multiple-choice-question .stats p,.multiple-select-question .stats p{font-family:nyt-franklin,Arial,helvetica,sans-serif;font-weight:500;color:#666;text-align:right;font-size:14px}@media only screen and (min-width:480px){.multiple-choice-question .counter,.multiple-select-question .counter{border-bottom:0 solid #ccc;padding-top:23px;padding-bottom:0;font-size:20px}}@media only screen and (min-width:480px) and (min-width:480px){.multiple-choice-question .counter,.multiple-select-question .counter{padding-top:47px;padding-bottom:39px;padding-bottom:0;position:absolute;display:inline-block;width:180px;left:-210px;text-align:right;top:0}}@media only screen and (min-width:480px){.multiple-choice-question .answer.question-unanswered:hover,.multiple-choice-question .done-button >.text-block:hover,.multiple-select-question .answer.question-unanswered:hover,.multiple-select-question .done-button >.text-block:hover{background-color:#053e69;color:#fff}}@media only screen and (min-width:480px){.multiple-choice-question,.multiple-select-question{max-width:600px;margin-left:auto;margin-right:auto;box-sizing:border-box}}.scorecard{margin-top:2em;font-family:nyt-cheltenham,georgia,times new roman,times,serif}@media only screen and (min-width:480px){.scorecard{max-width:600px;margin-left:auto;margin-right:auto;box-sizing:border-box}}.scorecard .scorecard-kicker{line-height:1.5;font-size:20px;display:block;font-weight:400;color:#656565}.scorecard .scorecard-inner{font-size:18px;line-height:1.66;font-weight:700;color:#323232;text-align:left}.stats{margin-top:2em}@media only screen and (min-width:480px){.stats{max-width:600px;margin-left:auto;margin-right:auto;box-sizing:border-box}}.stats p{font-family:nyt-franklin,Arial,helvetica,sans-serif;font-weight:500;color:#666;text-align:right;font-size:14px}@media only screen and (min-width:480px){.scorecard .scorecard-kicker{float:left;width:180px;margin:7px 0 0 -210px;text-align:right;font-size:30px}.scorecard .scorecard-inner{font-size:36px;margin-bottom:12px}}.lede-question-adventure .multiple-choice-question,.lede-question-adventure .multiple-select-question{border-bottom:none}.lede-question-adventure .multiple-choice-question .counter,.lede-question-adventure .multiple-select-question .counter{display:none}.lede-question-adventure .multiple-choice-question .response,.lede-question-adventure .multiple-select-question .response{border-left:none;padding-left:0}.lede-question-adventure .multiple-choice-question .response p,.lede-question-adventure .multiple-select-question .response p{font-size:16px;line-height:1.4;font-weight:400;font-style:normal;font-family:georgia,times new roman,times,serif;color:#000}@media only screen and (min-width:480px){.lede-question-adventure .multiple-choice-question .response p,.lede-question-adventure .multiple-select-question .response p{font-size:17px;line-height:1.625rem}}.lede-question-adventure .multiple-choice-question .text-block.lede-question p,.lede-question-adventure .multiple-select-question .text-block.lede-question p{text-align:center;font-size:20px;margin-left:auto;margin-right:auto}@media only screen and (min-width:480px){.lede-question-adventure .multiple-choice-question .text-block.lede-question p,.lede-question-adventure .multiple-select-question .text-block.lede-question p{font-size:27px}}.chapter-header{font-size:36px;text-align:center}.chapter-header em,.chapter-header strong{display:block}1

Read more →

China subjects some travelers to anal swabs, angering foreign governments.

#masthead-section-label, #masthead-bar-one { display: none }The Coronavirus OutbreakliveLatest UpdatesMaps and CasesRisk Near YouVaccine RolloutNew Variants TrackerAdvertisementContinue reading the main storyCovid-19: U.S. Vaccination Pace Increases to 2 Million Doses a DayChina subjects some travelers to anal swabs, angering foreign governments.March 5, 2021, 2:39 a.m. ETMarch 5, 2021, 2:39 a.m. ETThe arrivals hall at Shanghai Hongqiao International Airport in January.Credit…Aly Song/ReutersChina is requiring some travelers arriving from overseas to receive an invasive anal swab test as part of its coronavirus containment measures, a move that has outraged and shocked several foreign governments.Japanese officials said on Monday that they had formally asked China to exempt Japanese citizens from the test, adding that some who had received it complained of “psychological distress.” And the United States State Department last moth said it had registered a protest with the Chinese government after some of its diplomats were forced to undergo anal swabs, though Chinese officials denied that.It is not clear how many such swabs have been administered or who is subject to them. Chinese state media has acknowledged that some arrivals to cities including Beijing and Shanghai are required to take the tests, though the reports said the requirements might vary depending on whether the travelers were deemed to be high-risk.Chinese experts have suggested that traces of the virus may survive longer in the anus than in the respiratory tract and that samples of the former may prevent false negatives. China has imposed some of the strictest containment measures in the world, including barring most foreign arrivals, and has largely suppressed the epidemic.Lu Hongzhou, an infectious disease specialist at Fudan University in Shanghai, told the state-controlled Global Times tabloid that nasal or throat swabs could cause “uncomfortable reactions,” leading to subpar samples. He acknowledged that fecal samples could replace anal swabs, to prevent similar discomfort.But other experts — including in China — have questioned the need for anal samples. The Global Times quoted another expert, Yang Zhanqiu, as saying that nasal and throat swabs are still the most effective because the virus is contracted through the respiratory tract.Benjamin Cowling, a public health professor at the University of Hong Kong, said in an interview that even if someone did test positive on an anal swab but not a respiratory one, he or she would likely not be very contagious.“The value of detecting people with the virus is to stop transmission,” Professor Cowling said. “If someone has got an infection but they’re not contagious to anyone else, we didn’t need to detect that person.”A spokesman for the Chinese Foreign Ministry said this week that the government would make “science-based adjustments” to its containment policies.Professor Cowling said he did not know what the scientific rationale was behind the existing policies. “I presume there’s some evidence leading to this decision, but I haven’t seen that evidence,” he said.AdvertisementContinue reading the main story

Read more →

International Women's Day: Illustrating the Covid-19 pandemic

SharecloseShare pageCopy linkAbout sharingimage copyrightDr Radhika Patnala/Sci Illustrate/BBCThere’s barely any country in the world that hasn’t been touched by the coronavirus pandemic and its aftershocks. But with so much information out there, it’s sometimes hard to digest all the details and fully take it in.Ahead of International Women’s Day on 8 March, we invite you to meet three women who are using their artistic talents, combined with their expertise in the fields of science, health and technology to help the fight against coronavirus.Avesta Rastan: ‘You help out in whatever way you can’image copyrightAvesta Rastan/ www.azuravesta.comAvesta Rastan, 25, is a visual science communicator currently living in California. At the start of the pandemic, she realised there weren’t many infographics revealing how Covid-19 directly affected the human body.So the artist, who is of Iranian and Canadian heritage, and is a member of the Association of Medical Illustrators, saw a unique opportunity to use her skills and her training in pathological illustration (the drawing of disease) to help the wider public.”I saw lots of illustrations and 3D models of the virus itself and its protein but I didn’t really see what it did to us,” she explained.She started investigating and soon created an infographic that unexpectedly went viral on social media. Even the World Economic Forum shared it.image copyrightAvesta Rastan/ www.azuravesta.comShe was approached by people all over the world wanting to see the poster in different languages and offering to translate her explanations. It’s now available to download in 18 languages on her website.Rastan says: “I’m not a frontline worker; I’m not in health care, but you help out in whatever way you can and for me that was using my art.She adds science can have a reputation for being difficult to learn and that does deter people but illustrations bridge that gap and could encourage more to enter her field.”Science itself isn’t hard – it’s a natural process for humans; we’re naturally curious and want to understand how things work”, she adds.image copyrightAvesta Rastan/Azuravesta Design/BBC In the future she wants to be involved in building educational platforms. But for now, she’s spreading the word about her unusual career. “I have definitely noticed in the past 10 to 20 years there are more women in this field than men. In the older generations it was definitely a male dominated field but now things are changing,” she says.And while the pandemic has been a terrible thing for the world to go through, Rastan admits that for her it did offer a silver lining. She embarked on a freelance career and worked with academic researchers, medical tech start-ups, doctors and surgeons. image copyrightAvesta Rastan/ www.azuravesta.comRastan, who finds a lot of her inspiration comes from nature, has a new job in the US now. But she continues to spend her spare time on a passion project on social media called Lumi Science where she’s still visualising the virus and its variants. “Science communication is so key to society. When you understand something, you’re empowered to try to change it or try to mitigate the risk”, she says.Dr Radhika Patnala: ‘The pandemic woke everyone up’image copyrightRadhika Patnala/ www.sci-illustrate.comDr Radhika Patnala is a neuroscientist and the founder and director of the start-up Sci-Illustrate. The Indian-born entrepreneur, who studied in Singapore and Australia before moving to Munich, Germany, says one of the beauties of working in science is that the field is incredibly collaborative and crosses geographical and institutional boundaries.Her company creates science illustrations for a whole range of clients but she also has several passion projects underway, with the most recent focused on her response to the pandemic. image copyrightRadhika Patnala/ www.sci-illustrate.comIt’s a 10-part series of illustrations called Covid Dreams. “I came across this very interesting piece of information, that people who got Covid-19 were having weird dreams. I thought that was an amazing idea to explore. I also wanted to challenge myself to try to depict something which is very serious and slightly depressing, in an unusual and visually different way,” she says.Her series encompasses different parts of the coronavirus experience, from detailing the nucleo-protein packages within the virus to imagining what someone’s mouth inside the mask looks like. image copyrightRadhika Patnala/ www.sci-illustrate.comIt was when she was doing her doctorate, with a focus on immunology and epigenetics, that Patnala, 32, reconnected with her artistic side. “I’d be in a neuroanatomy lab and we would look at slices of mice and rat brains and stain them, so we could look at individual cells and the tissue architecture of the brain in detail. “A lot of my PhD involved looking under a microscope at neural tissue, how the different cells talk to each other and how beautiful the tissue architecture of the organ itself was,” she says.image copyrightRadhika Patnala/ www.sci-illustrate.comFor Patnala, the pandemic has not led to a significant difference to her day job and, with so many in the industry now focusing on virus illustrations, she was continuing to work on visualising other diseases for clients in need.”There are important things happening all the time in our industry – there are companies looking at cancer therapeutics and trying to find drugs for niche cancer types; there are people working on cardiovascular diseases,” she explains.Stating the science field has always had trouble getting money from policy makers, she suggests perhaps a change is on the way, adding: “The pandemic woke everyone up to the amazing work that people are doing in laboratories all the time.”Nujuum Hashi: ‘If I can fight coronavirus others can try’ image copyrightNujuum HashiWhen Nujuum Hashi, 26, caught coronavirus early last year, she refused to let it destroy her creative ambitions and all the dreams she had steadily been working towards over the past few years.Hashi had given up her career as a nurse in Somaliland to pursue art, despite her family’s misgivings about her chosen path, and she resolved that while the pandemic had knocked her strength, it wasn’t going to kill her spirit.Hashi, who is now living in Mogadishu, Somalia, had just returned from a trip to Kenya in April 2020 when she realised that she was sick. “First I had a headache, then I had a rough throat. I lost my sense of smell and I was shivering and cold; I had dizziness and a migraine. I lost my appetite and even my eyes were very dry and sensitive to light. My brain couldn’t do any creative work – I just felt incredibly flat.”image copyrightNujuum HashiBut while she was self-isolating, she realised it was important for her to stay connected to the world.”I still tried to do live Instagram art classes – even while I was sick – to entertain others. I’d teach people how to draw faces and hands and other things. “I wanted to show the world I was fighting corona and that I was doing my best. When I felt my brain was returning to a better place, I did an illustration of me boxing the corona as I wanted to show I was fighting this evil virus. I was angry about the virus and this was a celebration picture. “If I can fight it; others can try to do so as well.”image copyrightNujuum Hashi As well as illustrations focusing on her experiences, Hashi has been drawing and painting scenes to encourage others to take care and be more aware of the community around them. Her illustrations include an image of the Covid-19 virus on a world tour and a drawing in tribute to the frontline doctors and nurses trying to save lives.Hashi grew up in a medical family – her mother is a midwife, while her late father was an anaesthetist. And it was back in Hargeisa, Somaliland that Hashi herself trained and worked as a nurse. She said it was a job she loved as it meant she could help the community but there came a point in her life when the desire to create art overwhelmed her.image copyrightNujuum HashiShe says it is not easy being a female artist in Somalia but as a creative person, she feels a personal responsibility to share her talents with the world.While 2020 was a difficult year, she is optimistic about the future. She plans to continue seeking out more business opportunities, and she wants to use her art to tackle misinformation about the pandemic.”There’s a lot of misunderstanding in our country. Sometimes I have to show people that the right information is here and tell others to stop spreading the wrong information,” she says.The virus has had global ramifications with many calculating women will bear the brunt with long-lasting social and economic effects. But could the virus be the catalyst for change in traditionally male dominated fields? Reports suggest the pandemic has led to more women considering a career in the sciences. After all, as these three women stress, education leads to empowerment. Related Internet LinksAzuravesta Design – Scientific Art & AnimationSci-IllustrateNujuum.A.Hashi (@nujuumarts)The BBC is not responsible for the content of external sites.

Read more →

Covid variants: What happens when a virus mutates?

Surge testing is being used in parts of the UK to help control the spread of new variants from Brazil and South Africa.The Kent variant is now the most commonly found strain of Covid-19 in the UK and it’s more easily spread than the first variant, which arrived in Spring 2020. Scientists are looking at tweaking the coronavirus vaccines to make sure they continue to be highly effective. But where are these variants coming from? And why do viruses mutate?Health correspondent Laura Foster explains.

Read more →

Covid 19: 'His mental health has suffered all along'

Michael Benyo, who has dementia, hasn’t been able to properly see his family for a year, due to Covid-19 restrictions in his care home. His daughters Gillian and Jaqueline spoke to BBC Social Affairs correspondent Alison Holt, about their experience, and how they feel about changes that come into effect on 8 March. In a relaxation of the rules, care homes will allow one family member to visit their loved one. They will be able to hold hands, but won’t be allowed to hug.Produced by James MelleyFilmed by John BoonEdited by Alex Dackevych

Read more →

Investigation into Covid Origins Sought

• Virginie Courtier, Evolutionary geneticist, Institut Jacques Monod, CNRS, France (ORCID 0000-0002-9297-9230). • Francisco A. de Ribera, Industrial Engineer, MBA, MSc(Res), Data scientist, Madrid, Spain (ORCID 0000-0003-4419-636X) • Etienne Decroly, DR CNRS, molecular virologist, Aix Marseille University, France, (ORCID 0000-0002-6046-024X) • Rodolphe de Maistre, MSc engineering, MBA, ex auditor IHEDN, France (ORCID 0000- 0002-3433-2420) • Gilles Demaneuf, Engineering (ECP), Data Scientist at BNZ, Auckland, NZ, (ORCID: 0000-0001-7277-9533) (Co-Organizer) • Richard H. Ebright, Professor of Chemistry and Chemical Biology, Rutgers University, USA • André Goffinet, MD, PhD, Emeritus Professor, University of Louvain Med Sch, Belgium • François Graner, biophysicist, Research Director, CNRS and Université de Paris, France, (ORCID 0000-0002-4766-3579) • José Halloy, Professor of Physics, Biophysics and Sustainability, Université de Paris, France, (ORCID 0000-0003-1555-2484) • Milton Leitenberg, Senior Research Associate, School of Public Affairs, University of Maryland, USA • Filippa Lentzos, Senior Lecturer in Science & International Security, King’s College London, United Kingdom (ORCID 0000-0001-6427-4025) • Rosemary McFarlane, PhD BVSc, Assistant Professor of Public Health, University of Canberra, Australia (ORCID 0000-0001-8859-3776) • Jamie Metzl, Senior Fellow, Atlantic Council, USA (Co-Organizer) • Dominique Morello, Biologist, DR CNRS and Museum of Natural History, Toulouse, France • Nikolai Petrovsky, Professor of Medicine, College of Medicine and Public Health, Flinders University, Australia • Steven Quay, MD, PhD, Formerly Asst. Professor, Department of Pathology, Stanford University School of Medicine, USA (ORCID 0000-0002-0363-7651) • Monali C. Rahalkar, Scientist ‘D’, Agharkar Research Institute, Pune, India • Rossana Segreto, PhD, Department of Microbiology, University of Innsbruck, Austria (ORCID 0000-0002-2566-7042) • Günter Theißen, Dr. rer. nat., Professor of Genetics, Matthias Schleiden Institute, Friedrich Schiller University Jena, Germany, (ORCID 0000-0003-4854-8692) • Jacques van Helden, Professor of bioinformatics, Aix-Marseille University, France, (ORCID 0000-0002-8799-8584)

Read more →

Team of bioethicists and scientists suggests revisiting 14-day limit on human embryo

An international team of bioethicists and scientists, led by a researcher at Case Western Reserve University, contends it may be justified to go beyond the standing 14-day limit that restricts how long researchers can study human embryos in a dish. Going beyond this policy limit could lead to potential health and fertility benefits, and the authors provide a process for doing so.
In an article published March 5 in Science, Insoo Hyun, a bioethics professor at the Case Western Reserve University School of Medicine and the paper’s lead author, and colleagues urge policymakers and the International Society for Stem Cell Research (ISSCR) to consider “a cautious, stepwise approach” to scientific exploration beyond the 14-day limit.
“But first,” they write, “one must appreciate the scientific reasons for doing so. Any such proposed research must serve important goals that cannot be adequately met by other means.”
ISSCR is expected to soon release updated guidelines for stem cell and embryo research.
Among the potential benefits of studying human embryos beyond the 14-day limit include understanding how early development disorders originate and developing therapies that address causes of infertility, developmental disorders and failed pregnancy.
Since the first successful birth from in vitro fertilization in the late 1970s, human embryo research has been subject to limits of time and developmental benchmarks. The general rationale for imposing those limits was that, although considered acceptable to benefit human health and improve reproduction, in vitro research should conclude 14 days after fertilization — about when implantation in the womb is normally completed.

advertisement

National guidelines, laws and international norms have prohibited scientists from culturing human embryos for research after 14 days, or beyond the appearance of a structure called the “primitive streak,” which defines the period when principal tissues of the body begin to form and an embryo can no longer divide into identical twins. Thus, the 14-day limit allowed research to proceed until the human embryo in a dish starts to become biologically unique.
When this limit was put in place, there were no methods to culture embryos in a dish for anywhere close to two weeks.
But research since 2016 shows that it is likely possible to culture human research embryos past the two-week limit, and suggests that doing so will yield scientific insights that could prove important for human health and fertility.
The authors acknowledge that researchers should adhere to the 14-day limit, “unless a strong scientific justification can be offered to culture human embryos longer in locales where it would be legally permissible to do so. Any such proposed research must serve important goals that cannot be adequately met by other means.”
Hyun and colleagues propose six principles that can be used to weigh whether research on human embryos can move beyond the 14-day limit, in incremental, measured steps. They note their principles apply for extending the 14-day limit, but also for other complex research.
Among their principles, they emphasize that extended embryo culture should begin in small steps, with frequent interim evaluations. For instance, it would first be necessary to assess feasibility of culture past 14 days, and, if so, to assess whether those newly permitted experiments were informative enough to justify the further use of human embryos.
Their other principles include advocating for research proposals to be peer-reviewed by qualified and independent science and ethics committees; for public dialogue at the local institutional level and, more broadly.
“Realistically,” they conclude, “an incremental approach seems to be our only path forward, both from a scientific and a policy standpoint.”

Read more →

Less inflammation with a traditional Tanzanian diet than with a Western diet

Urban Tanzanians have a more activated immune system compared to their rural counterparts. The difference in diet appears to explain this difference: in the cities, people eat a more western style diet, while in rural areas a traditional diet is more common. A team of researchers from Radboud university medical center in the Netherlands, the LIMES Institute at the University of Bonn in Germany and the Kilimanjaro Clinic Research Center in Tanzania believe that this increased activity of the immune system contributes to the rapid increase in non-communicable diseases in urban areas in Africa.
The survey was conducted among more than 300 Tanzanians, some of whom live in the city of Moshi and some in the countryside. The team found that immune cells from participants from Moshi produced more inflammatory proteins. The people surveyed had no health problems and were not ill, but an activated immune system may increase the risk for lifestyle diseases, such as cardiovascular disease.
The researchers used new techniques to investigate the function of the immune system and the factors that influence its activity. Quirijn de Mast, internist-infectious diseases specialist at Radboud university medical center explains: “We looked at active RNA molecules in the blood — known as the transcriptome — and the composition of metabolic products in the blood.”
Major differences in diet
These analyses showed that metabolites derived from food had an effect on the immune system. Participants from rural areas had higher levels of flavonoids and other anti-inflammatory substances in their blood. The traditional rural Tanzanian diet, which is rich in whole grains, fibre, fruits and vegetables, contains high amounts of these substances. In people with an urban diet, which contains more saturated fats and processed foods, increased levels of metabolites that are involved in cholesterol metabolism were found. The team also found a seasonal change in the activity of the immune system. In the dry season, which is the time of harvest in the study area, the urban people had a less activated immune system.
Migration to the cities of Africa
It has been known for some time that a Western lifestyle and eating habits lead to chronic diseases. According to de Mast, two important findings have emerged from this study. “First of all, we showed that a traditional Tanzanian diet has a beneficial effect on inflammation and the functioning of the immune system. This is important because rapid urbanization is ongoing, not only in Tanzania, but also in other parts of Africa. The migration from the countryside to the city is leading to dietary changes and is accompanied by a rapid increase in the number of lifestyle diseases, which puts a heavy burden on the local healthcare systems. That is why prevention is essential, and diet can be very important for this.”
Western countries can learn from the results Second, these findings from Africa are also relevant for Western countries. Urbanization took place a long time ago in most western countries. By studying populations at different stages of urbanization, researchers therefore have unique opportunities to improve their understanding of how diet and lifestyle affect the human immune system.

Story Source:
Materials provided by Radboud University Medical Center. Note: Content may be edited for style and length.

Read more →

Proteomics analysis identifies potential drug targets for aggressive human cancers

Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic targets. They report in the journal Oncogene, the identification of “proteomic signatures” that are associated with clinical measures of aggressive disease for each of the seven cancer types studied. Some signatures were shared between different types of cancer and included cellular pathways of altered metabolism. Importantly, experimental results provided proof-of-concept that their proteomics analysis approach is a valuable strategy to identify potential therapeutic targets.
“There are two notable aspects of this study. One is that we explored the proteomic landscape of cancer looking for proteins that were expressed in association with aggressive forms of cancer,” said co-corresponding author Dr. Chad Creighton, professor of medicine and co-director of Cancer Bioinformatics at the Dan L Duncan Comprehensive Cancer Center at Baylor. “We analyzed protein data that included tens of thousands of proteins from about 800 tumors including seven different cancer types — breast, colon, lung, renal, ovarian, uterine and pediatric glioma — made available by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) mass-spectrometry-based proteomics datasets.”
Computational analysis for the CPTAC datasets identified proteomic signatures associated with aggressive forms of cancer. These signatures pointed at altered cellular pathways that might be driving aggressive cancer behavior and could represent novel therapeutic targets. Each cancer type showed a distinctive proteomic signature for its aggressive form. Interestingly, some signatures were common to different types of cancer.
The other aspect of this study was to provide proof-of-concept that the proteomic analysis was a useful strategy to identify drivers of aggressive disease that could potentially be manipulated to control cancer growth.
“That’s exactly what we were able to do with this new, very powerful dataset,” said co-corresponding author Dr. Diana Monsivais, assistant professor of pathology and immunology at Baylor. “We focused on the uterine cancer data for which the computational analysis identified alterations in a number of proteins that were associated with aggressive cancer. We selected protein kinases, enzymes that would represent stronger candidates for therapeutics.”
Of hundreds of initial candidates, the researchers selected four kinases for functional studies in uterine cancer cell lines. They found that the kinases not only were expressed in the uterine cancer cells lines, but also that manipulating the expression of some of the kinases reduced the survival or the ability to migrate for some uterine cancer cells. Cell migration is a property of cancer cells that allows them to spread cancer to other tissues.
This work is the result of a productive collaboration between two Baylor centers, the Dan L Duncan Comprehensive Cancer Center and the Center for Drug Discovery.
“Chad conducted this wonderful analysis on new CPTAC datasets and was interested in validating it in a human cancer. He approached us about performing functional studies to determine whether some proteins could translate to new targets for endometrial cancer,” Monsivais said. “Our experiments provided proof-of-concept that proteomics analysis is a useful strategy not only to better understand what drives cancer, but to identify new ways to control it or eliminate it.”
“Historically, researchers have only been generating transcriptomic data (the messenger RNA (mRNA) that is translated into protein). Looking at the protein data itself, which is made available by the CPTAC, enables researchers to extract a new layer of information from these cancers,” Creighton said. “In this study, we compared mRNA and protein signatures and, although in many cases they overlapped, about half the proteins in the proteomic signatures were not included in the corresponding mRNA signature, suggesting the need to include both mRNA and protein data in cancer studies.”

Story Source:
Materials provided by Baylor College of Medicine. Original written by Ana María Rodríguez, Ph.D.. Note: Content may be edited for style and length.

Read more →