The $8 Billion Children’s Vaccine Fund Kennedy Would Oversee

If confirmed by the Senate to be the nation’s health secretary, Robert F. Kennedy Jr. would have vast powers over immunization policies for children and adults.When President Bill Clinton worked with a bipartisan Congress to enact a federal program to guarantee vaccines for poor children, they agreed that the authority over buying shots from drug makers should rest with the health secretary. The bill’s drafters did not consider that an extremely vocal critic of childhood vaccines would emerge as a nominee for the role.That critic, Robert F. Kennedy Jr., comes before the Senate for confirmation hearings this week. If confirmed, he would have the power to limit or even cut off contracts with the makers of vaccines for more than half the nation’s children under the $8 billion dollar Vaccines for Children program.The program has been credited with raising national vaccination rates and protects nearly 38 million low-income and working-class children from diseases like polio, measles, whooping cough and chickenpox.Mr. Kennedy has said he would not take vaccines away from anyone, but he has a long history of questioning vaccine safety. The far-reaching authority he would wield over vaccine policy has become increasingly worrisome for public health experts, researchers and lawmakers from both parties.Some architects of the program are trying to persuade senators to oppose his nomination.“I think he’s dangerous to children’s health,” Donna E. Shalala, Mr. Clinton’s health secretary and a former Democratic congresswoman, said in an interview. She said she had spoken to Republican senators who expressed uneasiness about Mr. Kennedy, but would not name them.Confirmation hearings for Mr. Kennedy will begin on Wednesday before the Senate Finance Committee, and continue on Thursday before the Senate Health, Education, Labor and Pensions Committee. The back-to-back sessions will give senators of both parties an opportunity to ask Mr. Kennedy pointed questions about how he would oversee the nation’s large health agencies and vaccine policies.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.

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CDC Ordered to Stop Working With WHO Immediately

U.S. public health officials have been told to stop working with the World Health Organization (WHO), effective immediately.
A CDC official, John Nkengasong, MSc, PhD, sent a memo to senior leaders at the agency on Sunday night telling them that all staff who work with the WHO must immediately stop their collaborations and “await further guidance.”
Experts said the sudden stoppage was a surprise and would set back work on investigating and trying to stop outbreaks of Marburg virus and mpox in Africa, as well as brewing global threats. It also comes as health authorities around the world are monitoring bird flu outbreaks among U.S. livestock.
The Associated Press viewed a copy of Nkengasong’s memo, which said the stop-work policy applied to “all CDC staff engaging with WHO through technical working groups, coordinating centers, advisory boards, cooperative agreements, or other means — in person or virtual.” It also says CDC staff are not allowed to visit WHO offices.
President Trump last week issued an executive order to begin the process of withdrawing the U.S. from WHO, but that did not take immediate effect. Leaving WHO requires the approval of Congress and that the U.S. meets its financial obligations for the current fiscal year. The U.S. also must provide a 1-year notice.
His administration also told federal health agencies to stop most communications with the public through at least the end of the month.
“Stopping communications and meetings with WHO is a big problem,” said Jeffrey Klausner, MD, MPH, a University of Southern California public health expert who collaborates with WHO on work against sexually transmitted infections.
“People thought there would be a slow withdrawal. This has really caught everyone with their pants down,” said Klausner, who said he learned of it from someone at CDC.
“Talking to WHO is a two-way street,” he added, noting that the two agencies benefit from each other’s expertise. The collaboration allows the U.S. to learn about new tests, new treatments, and emerging outbreaks — information “which can help us protect Americans abroad and at home,” Klausner said.
The CDC details nearly 30 people to WHO and sends many millions of dollars to it through cooperative agreements. The U.S. agency also has some of the world’s leading experts in infectious diseases and public health threats, and the two agencies’ staffers are in daily contact about health dangers and how to stop them.
The collaboration halt isn’t the only global health effect of Trump’s executive orders. Last week, the president froze spending on another critical program, PEPFAR, or the President’s Emergency Plan for AIDS Relief.
The anti-HIV program is credited with saving 25 million lives, including those of 5.5 million children, since it was started by Republican President George W. Bush. It was included in a Trump administration freeze on foreign aid spending slated to last at least 3 months.
PEPFAR provides HIV medication to more than 20 million people “and stopping its funding essentially stops their HIV treatment,” International AIDS Society President Beatriz Grinsztejn, MD, PhD, said in a statement. “If that happens, people are going to die and HIV will resurge.”
A U.S. health official confirmed that the CDC was stopping its work with WHO. The person was not authorized to talk about the memo and spoke on condition of anonymity.
A WHO spokesperson referred questions about the withdrawal to U.S. officials.
Officials at HHS didn’t immediately respond to an emailed request for comment. And CDC officials didn’t respond to the AP’s request to speak with Nkengasong about the memo.

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All Federal Grants Suspended; What RFK Jr. Faces at Hearings; China Denies Lab Leak

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The White House budget office ordered a pause to all grants and loans disbursed by the federal government. (Washington Post)
The acting NIH director told scientists that clinical trials could continue, despite a pause in communications about their work. (NBC News)
Senior officials at U.S. Agency for International Development, including leaders overseeing global health aid, were put on paid leave in response to what an official characterized as resistance to President Donald Trump’s policy. (New York Times)
Have the Trump administration’s changes at federal health agencies affected you? Contact MedPage Today here to tell your story.
Here’s what Robert F. Kennedy Jr., Trump’s pick to lead HHS, might face in his nomination hearings this week. (KFF Health News)
The Wall Street Journal’s editorial board came out in opposition to Kennedy. (The Hill)
Kennedy said he’s open to seizing drug patents in a closed-door meeting with Senate Finance Committee staffers. (Politico)
Heart disease remains a leading cause of death, fueled by increases in risk factors like obesity and high blood pressure. (Circulation)
The shortage of immediate-release mixed amphetamine salts (Adderall) to treat attention-deficit hyperactivity disorder may have prompted a scramble towards alternative stimulants for kids. (American Academy of Pediatrics)
Trump said he would consider rejoining the World Health Organization, but said that they “would have to clean it up.” (Reuters)
China says it’s “extremely unlikely” that the COVID-19 pandemic was caused by a lab leak, as the CIA recently said. (The Hill)
While a bird flu pandemic in humans is not inevitable, recent developments seem worrisome. (New York Times)
The first U.S. outbreak of H5N9, a strain of bird flu rarer than H5N1, was reported on a California duck farm. (Reuters)
An infectious disease expert warned that windblown bird poop may transit the virus. (CBS News)
In South Carolina, bird flu is being blamed for soaring eggs prices of $9 a dozen. (The Post and Courier)
Acting HHS head Dorothy Fink, MD, said the agency will review government programs to ensure taxpayer dollars aren’t being used for elective abortions.
Trump signed executive orders to reinstate military service members who were dismissed for not getting vaccinated and eliminate “gender radicalism” in the military. (ABC News)
A cancer patient had her arm suddenly amputated. Her open-casket funeral for the arm went viral. (USA Today)

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When ‘Cancer’ Gets in the Way of Treatment

Some oncologists suggest that, for certain early cancers not at risk of spreading, the term “cancer” should be avoided.A diagnosis is more than words on a page. It’s everything that comes with it: the doctor’s tone of voice, a gentle touch of the hand, the pauses left so the patient can digest the news. All of these details subtly impart how you should think about the label that you’ve just been given.But one diagnostic word in particular threatens to derail any rational discussion of its meaning: cancer.“‘Cancer’ is just this panic word,” said Laura Scherer, a social psychologist at the University of Colorado who studies how doctors communicate risk. Patients compare hearing the term to “getting hit by a truck, like they can’t process anything that comes after,” she said.Kirsten McCaffery, a health researcher and psychologist at the University of Sydney’s School of Public Health, added, “That ‘cancer’ label is kind of an anxiety bomb that goes off for patients.”That’s why some oncologists argue that, for certain early cancers that aren’t at risk of spreading, the medical profession should do away with the word altogether.At the heart of the debate is the common breast cancer diagnosis DCIS, or ductal carcinoma in situ. The phrase, which describes cancer cells confined to the lining of the milk ducts, is somewhat of an oxymoron. The National Cancer Institute defines cancer as cells that, if left untreated, will grow uncontrollably and spread to other parts of the body; “in situ,” however, means limited to one place.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.

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For Children in Rural Mozambique, the Future Comes Into Focus

Over the past year, Muanema Fakira noticed something odd about the eyes of her 1-year-old daughter Sumaya. Her left eye was cloudy. It did not gleam with curiosity or glint in the sun. When the problem persisted, Ms. Fakira made the rounds to health clinics in their town in central Mozambique. Doctors said they could not help.But they knew of someone who could, if Ms. Fakira could take Sumaya, now 2, on a 100-mile journey to the coast.The family made the trip to the city of Quelimane, where Dr. Isaac Vasco da Gama examined Sumaya’s eyes and quickly diagnosed a congenital cataract.Ms. Fakira was skeptical — cataracts are for old people, she said. But Dr. da Gama explained that an infection at birth, or shortly after, can cause cataracts in children. The condition is particularly worrying because vision problems affect the development of a child’s physical function. But the good news, he said, was that the problem can be solved with a simple surgery, one he does a dozen times a week at Quelimane Central Hospital.This was particularly lucky for Sumaya because Dr. da Gama is one of just three pediatric ophthalmologists in Mozambique, a country of 30 million people.Dr. Isaac Vasco da Gama checking on 3-year-old Edilson, who was recovering from a retinoblastoma removed from his right eye at Quelimane Central Hospital.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.

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Water Bead Ingestion Linked to Neurotoxicity

Water bead toys have the potential to cause not only intestinal obstruction in children who ingest them, but also neurotoxicity, a case study suggested.
A 13-month-old female who was previously healthy presented to the emergency department with vomiting, lethargy, and weight loss over several weeks along with insomnia and facial dermatitis, reported a group led by Ashley Haugen, of the nonprofit advocacy organization That Water Bead Lady and the mother of the patient.
During an exploratory laparotomy, a mass consisting of water beads was removed from the child’s distal small intestine, Haugen and colleagues noted in Pediatrics.
Following removal of the mass, the patient’s facial dermatitis resolved. However, her speech along with gross and fine motor, sensory, and neurological functions continued to worsen. A second surgical procedure removed multiple fragments of water bead material from the child’s large intestine.
“This is an essential area for pediatric medical awareness because the dangers of water beads extend beyond what is commonly understood,” Haugen told MedPage Today in an email. “While physical obstructions are often the focus, the potential chemical toxicity of water beads, including neurotoxic and systemic effects have been largely overlooked.”
These beads are made of polymerized acrylamide monomer, which can be toxic at high levels. And they can clump together into a gelatinous mass.
“In cases where beads remain in the body for prolonged periods, chemical exposure could exacerbate the injury even beyond the physical obstruction,” Haugen added. “The material may contain residual monomers, degrade over time, impact digestive tract function, or disrupt gut microbiota — factors that cannot be fully replicated in testing or reliably predicted. Our paper highlights the importance of clinicians recognizing the duality of risk — both physical and chemical — which is often overlooked and should be an integral part of the clinical evaluation process.”
Along with marketing to children generally as toys, water bead sales are also targeted to children with autism and sensory processing disorders as sensory-based therapies, noted Patrick Reeves, MD, and Eric Pasman, MD, both of the Uniformed Services University of the Health Sciences in Bethesda, Maryland, in a commentary accompanying the case study in Pediatrics
“Without [pending] consumer protections, pediatrics should counsel families, including those at high risk based on age or developmental status, on the dangers of water bead ingestion,” they wrote. “There must be continued advocacy with the [Consumer Product Safety Commission] to mitigate the dangers posed by water beads.”
Overall, reports of children swallowing water beads have risen in the last decade, according to a systematic review presented at the American Academy of Pediatrics’ annual meeting in Orlando in September. And members of the American Medical Association House of Delegates also have called attention to reported injuries from the products.
In the case study by Haugen and colleagues, the patient had a normal developmental trajectory prior to water bead ingestion, meeting standard milestones like walking and speaking, as well as normal hearing.
However, at age 17 months, 3 months after surgical removal of the water bead mass, the patient’s pediatrician and medical records indicated that she demonstrated the following: motor incoordination, tremor, myoclonus, muscle weakness (minimal use of right hand), extremity hypotonia, gait abnormality, expressive receptive language delay, sensory processing issues with temperature and resistance to items touching feet and hands, delayed problem solving, and abnormal hearing.
Meanwhile, the patient’s brain MRI and chromosomal microarray were normal, “ruling out structural and genetic etiology,” Haugen and colleagues reported. And her parents confirmed with the water bead retailer and manufacturer that the products were made of polyacrylamide.
Because the patient’s symptoms and clinical progression were consistent with acrylamide exposure, her developmental pediatrician made a presumptive diagnosis of encephalopathy associated with acrylamide toxicity.
At age 20 months (6 months after surgery), formal assessment indicated the patient’s gross motor age was 18 months, her fine motor age was 16 months, her receptive language age was 10 months, and expressive language age was 12 months. And at 22 months of chronological age, histopathology of the colon showed mild eosinophilic inflammation and lymphoid aggregates consistent with an immune response.
Starting at age 17 months, the patient received specialized skills training four times per month for more than 3 months, which was aimed at addressing lack of coordination and fine motor skill challenges. Starting at 22 months, the patient received speech therapy eight times per month. And the patient also was initiated on a low-dose regimen of the sodium channel blocker oxcarbazepine (Trileptal) to mitigate hyperexcitability of damaged nerves.
At around 6 years of age, the patient was recommended to start 20 to 30 minutes of speech therapy five times a week and to get special education services in a general education setting to address functional deficits. At 8 years of age, the patient had made significant progress and speech therapy dropped to twice a week.
Limitations of the case study included lack of free acrylamide monomer blood level measurement, which is typically available only in research contexts, Haugen and colleagues noted. And “significant delay” between surgical intervention and identification of exposure “further precluded the possibility of obtaining accurate measurements.”

Jennifer Henderson joined MedPage Today as an enterprise and investigative writer in Jan. 2021. She has covered the healthcare industry in NYC, life sciences and the business of law, among other areas.

Disclosures
Haugen is president of the nonprofit advocacy organization That Water Bead Lady and mother of the patient described in the case study. Neither co-authors of the case study nor authors of the accompanying commentary reported any relevant conflicts of interest.

Primary Source
Pediatrics
Source Reference: Haugen A, et al “Intestinal obstruction and neurotoxicity associated with water bead ingestion” Pediatrics 2025; DOI: 10.1542/peds.2023-065575.

Secondary Source
Pediatrics
Source Reference: Reeves PT, Pasman EA “Risks of water bead ingestion” Pediatrics 2025; DOI: 10.1542/peds.2024-069447.

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Trump Administration Halts H.I.V. Drug Distribution in Poor Countries

PEPFAR’s computer systems also are being taken offline, a sign that the program may not return, as Republican critics had hoped.The Trump administration has instructed organizations in other countries to stop disbursing H.I.V. medications purchased with U.S. aid, even if the drugs have already been obtained and are sitting in local clinics.The directive is part of a broader freeze on foreign aid initiated last week. It includes the President’s Emergency Plan for AIDS Relief, the global health program started by George W. Bush that is credited with saving more than 25 million lives worldwide.The administration had already moved to stop PEPFAR funding from moving to clinics, hospitals and other organizations in low-income countries.Appointments are being canceled, and patients are being turned away from clinics, according to people with knowledge of the situation who feared retribution if they spoke publicly. Many people with H.I.V. are facing abrupt interruptions to their treatment.But most federal officials are also under strict orders not to communicate with external partners, leading to confusion and anxiety, according to several people with knowledge of the situation.U.S. officials have also been told to stop providing technical assistance to national ministries of health.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.

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