Doctors warn over water bead gifts for children
Emergency doctors in the UK have issued a safety warning over water beads, which could be given to children as gifts over Christmas.
Read more →Emergency doctors in the UK have issued a safety warning over water beads, which could be given to children as gifts over Christmas.
Read more →Shuttered drugstores pose a particular threat to older adults, who take more medications than younger people and often rely on pharmacies for advice.In July, a notice appeared on the front door of The Drug Store, the only pharmacy in rural Kernville, Calif. After 45 years, the proprietor wrote regretfully, it would be closing in four days and transferring customers’ prescriptions to a Rite Aid about 12 miles away.As the news spread, “there was a real sense of loss, a sense of mourning,” said Roberta Piazza Gordon, who owns Piazza’s Pine Cone Inn in Kernville. The pharmacy had served as a community crossroads where people chatted with neighbors and with the friendly staff.Its closing also created practical concerns. “We are an aging population,” Ms. Gordon, 69, said of the townspeople.She relied on The Drug Store for her blood pressure and cholesterol medications and for anti-inflammatories after injuring her shoulder. Her husband, who is 70, also regularly filled prescriptions there.At The Drug Store, “you got your flu shot, your Covid shot, your pneumonia shot,” she said.Now those services require a 20- to 30-minute drive to the Rite Aid, which is in Lake Isabella and which Ms. Gordon described as understaffed for its growing number of customers.“On any given day, there’s a line of 10 to 15 people waiting at the pickup window,” she said. Unlike The Drug Store, the Rite Aid doesn’t deliver.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.
Read more →A federal government shutdown probably wouldn’t be enough to derail the solid U.S. economy. But it could inject more uncertainty into an already murky economic outlook.Funding for the federal government will lapse at the end of Friday if Congress doesn’t reach a deal to extend it. It is still possible that legislators will act in time to prevent a shutdown, or will restore funding quickly enough to avoid significant disruptions and minimize any economic impact.But if the standoff lasts beyond the weekend, most federal offices will not open Monday, and hundreds of thousands of government employees will be told not to work. Others will be required to work without pay until the government reopens.For those workers and their families, the consequences could be serious, especially if the impasse drags on. Federal law guarantees that government workers will eventually receive back pay, but that may not come in time for those living paycheck to paycheck. And the back-pay provisions don’t apply to consultants or contractors. During the last government shutdown — a partial lapse in funding in late 2018 and early 2019 — federal workers lined up at food pantries after going weeks without pay.For the economy as a whole, the effects of a shutdown are likely to be more modest. Many of the most important government programs, like Social Security and Medicare, would not be affected, and government services that are deemed “essential,” such as air traffic control and aviation security, can continue at least temporarily. Federal workers who put off purchases are likely to make them once their paychecks restart.Forecasters at Goldman Sachs estimate that a shutdown would exert a small but measurable drag on the economy, reducing quarterly economic growth by about 0.15 percentage points for every week the lapse in funding continues. Most of that toll, though not all, would reverse in the next quarter. Other forecasters have released similar estimates.The Congressional Budget Office estimated in 2019 that the last shutdown, which ended after 35 days, had only a modest and short-lived impact on economic output. That was only a partial shutdown, however — large parts of the government, including the Departments of Defense, Labor, and Health and Human Services, remained open.A funding lapse now would affect a much larger part of the government, and therefore could cause more severe damage if it lasted a while. But that makes a long shutdown less likely, said Bobby Kogan, a former budget official in the Biden administration who now works at the Center for American Progress. He noted that the last shutdown had ended when it appeared that Transportation Security Administration screeners were about to stop showing up for work.“Part of the reason these things don’t end up being catastrophic is because we stop it before it gets catastrophic,” Mr. Kogan said.But economists warn that even if the direct effects of a shutdown are limited, the dysfunction it represents could have consequences in the long run. Government contractors may be more reluctant to hire workers and make investments if they think they can’t count on the federal government to be a reliable customer. Bond investors may demand a higher return to buy Treasury securities, in the form of higher interest rates, if they worry that political turmoil has made the U.S. government more of a credit risk.“The natural concern is that this is just a prelude of what we’re going to get over the next four years,” said Kathy Bostjancic, chief economist for Nationwide, the insurance company. “It’s just another layer of uncertainty and maybe caution that can work against the economy.”The economy is relatively healthy by most measures, with unemployment low, consumer spending strong and inflation much cooler than it was two years ago. That momentum means the economy can probably withstand the modest drag of a shutdown without running much risk of a recession.But recent economic data have sent conflicting signals, with some measures suggesting that inflation could be picking back up and others that the labor market could be starting to crack.Uncertainty about what policies the incoming administration will pursue has further clouded the economic outlook. On Wednesday, policymakers at the Federal Reserve cut interest rates by a quarter percentage point, but signaled that cuts next year were likely to be fewer and were not guaranteed.A government shutdown would complicate the picture for the Fed, and not only by adding more uncertainty to the economic outlook. It could also imperil the data that policymakers rely on to make their decisions. Past shutdowns forced the government to delay or even cancel reports on jobs, inflation and other measures.“If we do have a big delay in the economic data, I think it’s going to be really hard for the Fed to provide a whole lot of guidance,” said Michael Pugliese, senior economist at Wells Fargo.The impact of such uncertainty is hard to measure, Mr. Pugliese said, but it is real.“I don’t think that’s completely costless even if you don’t see it in the next G.D.P. report,” he said.
Read more →Before the answers to life’s questions fit in our pocket, you used to have to turn a dial. If you […]
Read more →Before the answers to life’s questions fit in our pocket, you used to have to turn a dial. If you […]
Read more →Credit: Donny Bliss/NIH
This year on the NIH Director’s Blog, we covered a wide range of NIH-supported research from across our institutes and centers. We explored exciting new findings that came from clinical trials and basic research, introduced us to promising new technologies, gave us insights into everything from our genetic makeups to our brain function to our immunity, and have important implications for future advances in disease prevention and treatment. While it would be difficult to sum up all we covered, here are some highlights of research findings reported in 2024.
Most Detailed 3D Reconstruction of Human Brain Tissue Ever Produced Yields Surprising Insights
Published May 30, 2024
Findings published in numerous journals this year helped us learn more about the human brain. In one fascinating example, published in Science, and supported by the NIH Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative, a research team reported the creation of the most detailed nanoscale resolution map ever produced of a cubic millimeter of brain tissue, about the size of half a grain of rice. To capture the immense number of cells, blood vessels, and neural connections in the sample in vivid detail, the researchers sliced the tissue into 5,000 thin layers and used electron microscopy to amass 1,400 terabytes of imaging data. They then used artificial intelligence (AI) models to create a 3D reconstruction of the tissue. The map they created revealed multiple brain structures that have never been seen before and has the potential to help us better understand both normal and disordered brain function.
See also: the unveiling of the first complete connectome of the fruit fly brain, the silencing of a toxic protein in the brain using an epigenetic editor which offers a potential path to treating prion diseases, and the introduction of a computerized brain implant that can decode internal speech.
Energy-Producing Enzyme Fuels the Brain with Promise for Treating Parkinson’s Disease
Published September 12, 2024
Studying the brain also helps researchers gain insights into what happens in brain-related diseases, an effort that could aid in prevention and treatment. This is evident in a study we covered from Science Advances identifying an energy-producing enzyme in the brain, that, when its activity is boosted, might potentially afford some protection against Parkinson’s disease. For the approximately one million Americans with Parkinson’s disease today, current treatments help to relieve symptoms but don’t stop the disease from progressing. These findings raise the possibility that drugs that enhance the activity of this enzyme may fuel the brain, helping to protect essential dopamine-producing neurons to treat or even prevent Parkinson’s disease, as well as other neurodegenerative conditions.
See also: findings showing that using treatments that use our immune systems to fight disease could help clear the amyloid plaques that build up in and worsen symptoms of Alzheimer’s disease, and research that suggests that having just one copy of a protective gene variant may be enough to delay cognitive impairment in people genetically predisposed to developing early-onset Alzheimer’s.
AI Tool Using Single-Cell Data Has Promise for Optimally Matching Cancer Drugs to Patients
Published May 9, 2024
We covered many studies this year that utilized AI technology, and several of them specifically showed us ways that AI could be harnessed for use in cancer detection and diagnosis. In a proof-of-concept study reported in Nature Cancer, a research team developed an AI-driven tool that can predict a cancer’s treatment responses from bulk RNA data by zeroing in on what’s happening in single cells. The research team built AI models for 44 drugs approved by the FDA and found that the tool predicted the success of targeted treatments against cell lines with a high degree of accuracy. The researchers made the tool available to other scientists with the hope that this kind of research could one day help doctors more precisely match patients to their optimal cancer treatments.
See also: findings suggesting an AI tool can determine in 10 seconds whether part of a cancerous brain tumor remains during brain surgery for glioma, and a study demonstrating that a “ChatGPT-like” AI system can perform a wide range of cancer evaluation tasks and outperforms current AI methods in tasks like cancer cell detection and tumor origin identification.
Study Offers New Clues to Why Most People with Autoimmune Diseases Are Women
Published February 15, 2024
Research findings often give us clues to answering long-held questions like this one: Why are most people with a chronic autoimmune condition—such as rheumatoid arthritis or multiple sclerosis—women? This study, in Cell, suggests this difference might be due to the fact that females have two X chromosomes while males have and X and a Y. More specifically, it has to do with molecules called Xist (pronounced “exist”), that are encoded on the X chromosome and transcribed into long non-coding stretches of RNA, only when there are two X chromosomes. This important discovery points to potential new ways to think about the causes for autoimmune conditions that affect millions of people around the world.
See also: findings that offer clues to why some people have rheumatoid arthritis pain without inflammation, and new insights into how a key immune checkpoint works that have implications for treating cancer and autoimmune diseases.
Insights into Molecular Basis of PTSD and Major Depression Could One Day Aid in Diagnosis and Treatment
Published June 13, 2024
Researchers are also learning a great deal about the brain in relation to our mental health. In this study, reported in Science, a research team used a comprehensive approach to examine multiple biological processes within the brain to learn more about the molecular basis of stress-induced mental health disorders like post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). The researchers identified important roles for known stress-related pathways in brain changes underlying these disorders and hope their findings could eventually shed light on why some people develop these stress-related anxiety disorders while others don’t.
See also: findings that suggest new experiences can refresh memories of past events which helps our understanding of PTSD, and insights into the brain effects of psilocybin that show the drug could possibly have potential for treating substance use and mental health disorders.
Many People with Long COVID Have Signs of Persistent SARS-CoV-2 Proteins, New Findings Show
Published October 31, 2024
Researchers are working to understand the underlying reasons why people develop Long COVID, who is most likely to get it, and how best to treat and prevent it. A study supported by the NIH Researching COVID to Enhance Recovery (RECOVER) Initiative, with findings reported in Clinical Microbiology and Infection, found that people with Long COVID were twice as likely to have remnants consisting of SARS-CoV-2 protein in their blood as people with no lingering symptoms. These findings will lead to additional studies that will help us better understand what causes some people to be at higher risk for Long COVID.
See also: research demonstrating that an antibiotic compound can target hard-to-treat infectious bacteria while sparing the gut microbiome in mice, and findings in tuberculosis immunity that point toward new approaches for treatment and prevention.
Read more →Patients most “in need” should be able to see the same doctor at every appointment in their local GP surgery, the government says.
Read more →Getty ImagesThis is the third feature in a six-part series that is looking at how AI is changing medical research and treatments.
Read more →The Food and Drug Administration released final rules on labeling foods as “healthy,” tightening limits for sugar, sodium and saturated fat.The Food and Drug Administration on Thursday updated the definitions of the term “healthy” for labeling on foods, a move that reflected changes in nutrition and that tightened limits on saturated fat, sugar and salt in food that could be sold under that claim.The effort, while seemingly an inconsequential update to a 30-year-old term, set off a veritable food fight of lobbying over which foods made the cut and whether the F.D.A. would violate First Amendment protections in trying to define “healthy.”The F.D.A. said Thursday that its policy, outlined in a final rule, was meant to “empower consumers” by helping them quickly spot nutritious food at the grocery store. The text of the rule said it was part of the agency’s work “to help reduce the burden of diet-related chronic diseases.”“It’s critical for the future of our country that food be a vehicle for wellness,” Dr. Robert Califf, the F.D.A. commissioner, said in a statement. “Improving access to nutrition information is an important public health effort the F.D.A. can undertake to help people build healthy eating patterns.”The 318-page rule sets forth highly specific guidelines around what food manufacturers can label “healthy” or other terms, like “healthful” or “healthiest.” For instance, a 50-gram serving of a dairy product must contain no more than 5 percent of a person’s daily sugar level and 10 percent of a person’s daily salt and saturated fat limit. Similar standards would apply to fruits, grains, vegetables, meat and other foods. The new definition would include some processed and packaged food and several items previously excluded from the definition of “healthy,” like nuts, seeds, salmon, some oils and water.Robert F. Kennedy Jr., who is meeting with lawmakers this week to shore up support for his upcoming confirmation hearings to become secretary of the nation’s top health agency, campaigned for President-elect Donald J. Trump on a message of making the nation healthier through more nutritious food. He criticized the food industry, saying it was poisoning children with artificial additives and ultra-processed foods.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.
Read more →The U.S. provides nearly half of the aid for global health, including childhood vaccination, H.I.V. treatment and disease surveillance.The election of Donald J. Trump, with his mistrust of international institutions and his history of proposing deep cuts to foreign aid, has complicated a perilous landscape for global health organizations that were already in a frantic competition for sharply reduced funds.Organizations that support the cornerstone health programs to vaccinate children, treat people with H.I.V. and stop the next pandemic through disease surveillance, among other goals, are seeking billions of dollars from high-income countries.Their demands for support reflect mounting health challenges: Rates of infection with dengue fever are exploding in Latin America. The mutated mpox virus is increasingly transmissible between people, and there are fears that H5N1, avian influenza, is also evolving to spread between humans. Deaths from cholera, an ancient scourge, and measles are rising. The parasite that causes malaria is increasingly resistant to the drugs to treat it, and an invasive malarial mosquito is threatening African cities.The organizations seeking financial commitments and the countries that fund them have helped save millions of lives in developing countries. The global rate of child mortality has dropped by more than half in the two decades since 2000. Malaria infections plummeted as bed nets and better drugs were distributed. H.I.V. went from being the top global killer to, in many places, a well-managed chronic illness.The reality that these organizations are unlikely to get anywhere near the amount of money they are seeking is driving debate about whether — and how — the current global health system should be restructured.Global health priorities are now competing with climate change and wars for funding, and aid budgets have already been cut in major donor countries, including Britain, Germany and Japan. Health organizations are bracing for the likelihood that the second Trump administration will sharply reduce contributions from the United States, as well.We are having trouble retrieving the article content.Please enable JavaScript in your browser settings.Thank you for your patience while we verify access. If you are in Reader mode please exit and log into your Times account, or subscribe for all of The Times.Thank you for your patience while we verify access.Already a subscriber? Log in.Want all of The Times? Subscribe.
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