Cats Are So Not Appreciated. Think Again.

Researchers who work on the genomes of domestic and wild cats say their DNA holds clues to human as well as feline health.Leslie Lyons is a veterinarian and specialist in cat genetics. She is also a cat owner and general cat partisan who has been known to tease her colleagues who study dog genetics with the well-worn adage that “Cats rule. Dogs drool.”That has not been the case with research money and attention to the genetics of disease in cats and dogs, partly because the number of dog breeds offers variety in terms of genetic ailments and perhaps because of a general bias in favor of dogs. But Dr. Lyons, a professor at the University of Missouri, says there are many reasons cats and their diseases are invaluable models for human diseases. She took up the cause of cat science this week in an article in Trends in Genetics.“People tend to either love them or hate them, and cats are often underappreciated by the scientific community,” she writes. But, she says, in some ways the organization of the cat genome is much like the human genome, and cat genomics could help in the understanding of the vast amount of mammalian DNA that does not constitute genes, and is poorly understood.Among the advances in veterinary medicine that have benefited humans, she pointed out that remdesivir, an important drug in combating Covid, was first successfully used against a cat disease caused by another coronavirus.She is the director of the 99 Lives Cat Genome Sequencing Initiative and as part of that project, she and a group of colleagues, including Wes Warren at the University of Missouri and William Murphy at Texas A&M University, recently produced the most detailed genome of the cat to date, which surpasses the dog genome.“For the moment,” Dr. Lyons said.I spoke last week with Dr. Lyons, Dr. Warren and Dr. Murphy, who refer to themselves as Team Feline. Dr. Lyons was visiting Texas, and with two of her colleagues she talked about why the genomes of cats are important to medical knowledge.I report on animal science, and over the years, I admitted to the members of Team Feline, I seem to have written more about dogs than cats. The dog-cat rivalry in genomic science is mostly a good-natured rivalry, but just to assess what I was getting myself into I first asked about the scientists’ nonscientific approach to cats and dogs.The conversation has been edited for length and clarity.First, their personal preferences:Dr. William Murphy: I do have cats and dogs as pets, but I prefer cats.Dr. Wes Warren: I’m a dog owner. Unfortunately I’m allergic to cats.Dr. Leslie Lyons: He has a very expensive dog that keeps having problems.Why were you moved to write the article promoting the cause of cat science?Dr. Lyons: Throughout my career, I’ve been trying to get people to recognize that our everyday pets have the same diseases as us and can really provide important information if we can understand what makes them tick a little bit better, how their genomes are constructed.A Pallas’s cat, or manul. Wildscotphotos/AlamyYou have high quality genomes of several species of cats beyond the domestic cat?Dr. Lyons: We already have the lions and tigers, the Asian leopard cat, Geoffroy’s cat, a half-dozen species with really, really good genomes that are even better than the dog genomes at this point in time.Dr. Murphy: By far. It was actually better quality than the human reference genome until very recently. The goal is to have the complete encyclopedia of the cat’s DNA, so we can actually fully understand the genetic basis for all traits in the cat.Dr. Lyons: For example the allergy gene that Wes is allergic to. We completely understand that gene now. We can maybe even knock it out of the cat to produce cats that are more hypoallergenic or at least understand what elicits the immune response better.How are cat diseases a good model for human diseases?Dr. Lyons: What we’re discovering is different species have different health problems. We should really be picking the right species.Dr. Warren: We know that dogs get cancer more frequently, similar to ourselves. Cats don’t get cancer very often. And that’s a fascinating story of evolution. So are there signals or clues in the genome of the cat that allows us to zero in better on why cats get certain types of cancers and understand the differences among dogs, cats and humans.How about the cats that are subjects of the research?Dr. Lyons: Genomic research is fantastic because all we need is maybe a blood sample. And so once we have the blood sample, we don’t have to do experimentation on an animal. We’re actually observing what animals already have. We’re working with the diseases that are already there.What about wild species?Dr. Murphy: High quality genomes for wild cats can aid in their species survival plans and their recovery in the wild.Dr. Lyons: We see half a dozen health problems in wild felids. We have a study of transitional cell carcinoma in fishing cats, inherited blindness in black-footed cats, polycystic kidney disease in Pallas’s cats. Snow leopards have terrible eye problems, probably because of inbreeding in zoos. So understanding their genomes can help us to stop those problems in the zoo populations, and that will help humans with the same conditions as well.How about ancient DNA and cats? There’s been a lot of work on that in dogs. How is that progressing in cats?Dr. Lyons: A couple of groups are moving forward with ancient DNA. I worked on some mummy cats and we showed that the mitochondrial DNA types that we found in the mummified cats are present more commonly in Egyptian cats today than they are anywhere else. So the cats of the pharaohs are the cats of present day Egyptians.To switch gears: I’ve always been a dog person but I’ve been thinking about getting a cat. Any tips?Dr. Lyons: Get two. They’ll be buddies. And give them something to scratch. Otherwise it is going to be your couch.

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Zoo Animals Are Getting Experimental Coronavirus Vaccines

Big cats, ferrets, apes and bears are benefiting from a gift of 11,000 doses, but vaccines for pets are not recommended.The Oakland Zoo in California started this week with bears, mountain lions, tigers and ferrets, the first of about 100 animals that are set to receive an experimental vaccine against the coronavirus over the summer.Zoetis, a veterinary pharmaceutical company, is donating 11,000 doses of the vaccine to about 70 zoos as well as sanctuaries, universities and other animal conservation sites in 27 U.S. states, and the Oakland Zoo is one of the first to benefit. The vaccine is solely for animals, goes through a different approval process than for people, and cannot be used to protect humans.“It means a lot more safety for our beautiful animals,” Dr. Alex Herman, said vice president of veterinary services at the Oakland Zoo. “Our very first animals to get vaccinated at the zoo were two of our beautiful and elderly tigers.”The Oakland Zoo has not had any cases of animals infected with SARS-CoV-2, the virus that causes Covid in humans. But the zoo has taken extraordinary precautions, Dr. Herman said, by requiring that keepers maintain a safe distance from the animals and wear protective equipment.Big cats and other vulnerable animals like gorillas have, however, been infected at zoos in the United States and elsewhere. The San Diego Zoo in February vaccinated apes with the Zoetis vaccine, first tested in mink.The company, based in New Jersey, has also provided the same experimental vaccine to mink farmers in Oregon after the state ruled this spring that all farmed mink had to be vaccinated. The U.S. Department of Agriculture has approved the vaccine for experimental use “on a case-by-case basis,” according to Christina Lood, a senior communications director for Zoetis.The vaccine donation is the latest development in the patchwork reaction to animals that have become infected with the virus.From the start of the pandemic, pet owners, zookeepers, fur farmers and scientists all had their own particular concerns about animal infections. Pet owners have worried about the health of beloved cats and dogs, while epidemiologists and public health officials have cautioned that some animal species — domestic or wild — could become a reservoir where the virus can live and mutate even as the world tries to stamp it down in people.A staff member at the Oakland Zoo giving a ferret an experimental Covid vaccine. Zoetis/Oakland ZooInfections at Danish mink farms caused Denmark to destroy its entire mink population of about 17 million. Russia approved a vaccine for mink and other animals and has reportedly begun vaccinating cats and dogs.The U.S. Department of Agriculture has not considered any vaccine candidates for cats or dogs, and veterinarians have consistently noted that there is no evidence that pets transmit the virus to humans. The virus did, however, pass from farmed mink to humans.Scientists continue to find, however, that both cats and dogs catch the virus from their owners. Cats are more susceptible and although most have mild symptoms, several studies have reported cats with severe symptoms. One cat in Britain had to be euthanized.Dr. Dorothee Bienzle, a veterinarian and immunologist at the University of Guelph, in Ontario, who recently completed a study of cats and dogs living in households with humans who had Covid, found several cases of cats with severe symptoms. But she said that to definitively pin the symptoms on the coronavirus, all other illnesses would have had to be excluded; that wasn’t possible in her study, which depended on blood samples and owner descriptions of symptoms.Dr. Karen Terio, a veterinarian and pathologist at the veterinary school at the University of Illinois at Urbana-Champaign, echoed that sentiment, saying, “I have heard of cats with severe clinical signs but had not seen any cases where they could confirm that the signs were due to SARS-CoV-2.”At the recent online meeting of the European Congress of Clinical Microbiology & Infectious Diseases, Dr. Bienzle presented preliminary results of the research she and her colleagues had conducted.They first tested cats and dogs in households where humans had tested positive for the coronavirus. “We targeted a population that was likely to be positive,” Dr. Bienzle said.They found, as expected, that more cats than dogs tested positive, 67 percent compared with 43 percent. Also, in cats, time spent with owners, particularly sleeping on the same bed, increased their chances of infection. That was not true with dogs.The researchers then tested cats admitted to shelters and cats brought to low-cost clinics for neutering. These cats, which were not known to have lived with infected humans, had a remarkably lower incidence of infection, 9 percent for cats in shelters, and only 3 percent for cats brought to the clinics.Dr. Bienzle said the advice for pet owners has remained consistent throughout the pandemic. If you have Covid, you should isolate from your pets as you would from a human. Neither the United States nor Canada support the vaccination of pets. Dr. Bienzle said human transmission to the animals could be prevented with social distancing and masks.Researchers at sanctuaries and those working with vulnerable species like bats have adopted stricter measures to protect the animals from infection.For zoos, the question is not whether to vaccinate, but how to approach the patient when it’s a tiger. “With lots of positive reinforcement,” Dr. Herman said. The zoo trains its animals by giving them rewards to voluntarily present themselves to be jabbed. It’s pretty much the same idea as getting a lollipop after a shot, although the animals seem more willing to volunteer than humans.“The tiger leans against the fence,” Dr. Herman said. “The thousand-pound grizzly bear leans against the fence.”Good tiger. Good bear.

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Covid-Sniffin

Logistics, cost and official standards are needed for the dogs to fulfill their potential in medical fields.Dog noses are great Covid-19 detectors, according to numerous laboratory studies, and Covid sniffing dogs have already started working in airports in other countries and at a few events in the United States, like a Miami Heat basketball game.But some experts in public health and in training scent dogs say that more information and planning are needed to be certain they are accurate in real life situations.“There are no national standards” for scent dogs, according to Cynthia M. Otto, director of the Penn Vet Working Dog Center at the University of Pennsylvania School of Veterinary Medicine and one of the authors of a new paper on scent dog use in Covid detection.And although private groups certify drug-sniffing and bomb and rescue dogs, similar programs for medical detection do not exist, according to the new paper in the journal Disaster Medicine and Public Health Preparedness.Lois Privor-Dumm, a public health researcher at Johns Hopkins University and the senior author of the paper, said there was no question that dogs have great potential in medical fields. But she wants to explore how they could be deployed on a large scale, such as by the government.“What are all the ethical considerations? What are the regulatory considerations? How practical is this?” she asked. Not only the quality of detection but logistics and cost would be central to any widespread application, as with any public health intervention.Quality control is a first step, and a large one. Medical scent detection is more complicated than drug or bomb detection, Dr. Otto said. A dog working an airport for drugs or explosive detection has a consistent context and a fairly straightforward target odor. In Covid detection, researchers know that the dogs can distinguish an infected person’s sweat or urine. But they don’t know what chemicals the dog is identifying.Because human scents vary, medical detection dogs have to be trained on many different people. “We have all of the ethnicities and ages and diets and all of these things that make human smell,” Dr. Otto said.The symptoms of many medical conditions are similar to those of Covid, and dogs that detect scents associated with fever or pneumonia would be ineffective. So the human subjects used in training dogs, Dr. Otto said, must include “lots of people that are negative, but might have a cough or might have a fever or other things.” If the dogs mistook flu for Covid, that would obviously be a crucial mistake.Sniffer dog training in Libourne, France, in January. Philippe Lopez/Agence France-Presse — Getty ImagesAlso, dogs can be trained on sweat, or saliva or urine. In the United Arab Emirates, the dogs worked with urine samples. In Miami, they just walked along a line of people.Any positive cases of Covid infection that the dogs detect are usually confirmed with what is now the gold standard for confirming the presence of the coronavirus, a P.C.R. test. A review of research published last week concluded, however, that dogs performed better than the test.But these are experimental results. Dogs do well in detecting explosives and other substances at a distance, but so far Dr. Otto said she was not aware of published research attesting to the accuracy of dogs sniffing people in a line rather than urine or sweat.If the government were to conduct or approve dogs for Covid detection in an official way, some standards would have to be established on how dogs should be trained and how their performance should be evaluated. Dr. Otto is on a committee at the National Institute of Standards and Technology now meeting to develop standards for scent detection dogs in a variety of situations, including detection of Covid.She said that even if standards are clearly set, finding enough dogs to conduct widespread scent detection is another hurdle. Trained dogs are not easy to come by. “We have a shortage of dogs in this country for bomb detection. We’ve been dealing with that for years,” she said.Dogs can be retrained from one scent to another, but that itself can be tricky. “Some countries are actually taking their dogs that are trained on bombs and training them on Covid. But you know, all you have to do is think about at an airport, if you have a dog that sniffs both Covid and bombs and they alert, what do you have?”Well-trained dogs are also costly and require paid, well-trained human handlers. According to the report, dogs may cost $10,000 and scent training per dog is $16,000. The Transportation Security Administration, for example, has a $12 million training facility in San Antonio for explosive detection dogs and handlers, and estimates the training cost for dogs and handlers at $33,000 for explosive detection and $46,000 for passenger screening.All these issues will determine how dogs are used in the future. Their ability is a given. “I think they absolutely can do it.” Dr. Otto said. “It’s just how we implement them.”

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Why Do Humans Feed So Many Animals?

In England and America, selling bird seed for feeders is a big business. In Delhi, people toss bits of meat into the air for black kites. Fleets of ships ply the oceans to catch fish for domestic cats, the descendants of predatory land animals.Humans feed animals all the time, whether it’s our pets, the chickens we plan to eat or the ducks at the park pond, even though we shouldn’t.Throughout history in fat years and lean across many cultures, sometimes with no apparent reason, humans have fed animals of every imaginable stripe in every imaginable way. Some researchers think the desire to give food to other animals may drive domestication as much as the human desire to eat them does.Our Stone Age leftovers from the hunt may have fostered the domestication of dogs. Some of us give our beloved dead to vultures, which is a problem when the birds disappear. We fed and feed cats both tame and feral, sharks, alligators, deer, hedgehogs, bears, pigeons of all sorts, ducks, swans, zoo animals, lab animals, pets, farm animals and more.Now, a group of researchers in Britain is asking: Where does this desire to give food to other animals come from, and what has it meant for animals, humans and their shared environments?One striking possible answer is extinction. Domestication may be the death knell for wild progenitors. The ancestors of horses and cattle are gone. And while there are still wolves around, they are not thriving the way dogs are.Some feeding of animals is purely practical. You feed chickens today if you want to eat their eggs, or their wings, tomorrow. You can’t ride a starving horse. Animals used for experiments in laboratories have to be kept alive to get cancer.But a lot of feeding is unrelated to any return on investment. The black kites of Delhi reach population densities that may be the highest for raptors anywhere because of accidental and purposeful feeding. They rely on garbage and on the tasty and nutritious pests that garbage attracts. And they also benefit from the charity of Muslims who follow a tradition of tossing bits of meat into the air for the birds.Many Indians feed street dogs as a matter of course, treating them as animal neighbors. In a small city near Ahmedabad where I reported on anti-rabies efforts, residents told me that you can’t just give dogs plain leftover bread. You have to put some clarified butter on it, to make it palatable. The residents were middle class, and had both bread and butter to give, but I also met people who lived by the side of the road, with nothing more than mattresses and a few pots, who shared their food with dogs.Almost nothing about humans feeding animals is fully understood, largely because scholars have not given the subject a great deal of attention. And that, most of all, is what the researchers in England and Scotland want to change. With a four-year grant of more than $2 million from the Wellcome Trust, five researchers are pursuing a collaborative multidisciplinary attempt to give animal feeding its due, and begin to answer some puzzling questions. They call their project, “From ‘Feed the Birds’ to ‘Do Not Feed the Animals.’”Naomi Sykes, an archaeologist at the University of Exeter, is the moving force behind the project.The first chickensChickens were one of the animals that led Dr. Sykes to this point of view, she said. She was working on some ancient sites in Britain and was surprised by what isotope studies of fossilized chicken bones suggested about the birds’ diet. Isotopes are different forms of elements like carbon and nitrogen, and researchers use the amount of one versus another to determine what animals or humans ate. Different grains or even grains from different geographical regions give different results, or values.“At sites where there’s a lot of chicken sacrifice to the gods of Mercury and Mithras” during the Roman occupation of Britain, Dr. Sykes said, “some of the values of those chickens just looked really bizarre.” It seemed the chickens were eating some sort of special diet. She talked to colleagues who told her that, in fact, chickens in Roman times that were to be sacrificed were sometimes fed a special diet of millet in preparation for their ritual slaughter.Eventually, chickens became a major food source. But they are one example, Dr. Sykes said, of a process of domestication in which feeding animals was more important at first than eating them.In addition to their religion, the Romans brought with them dogs and cats. Remains of the cats are found in settlements along with remains of wildcats that seemed to be living with or near humans as well, not as pets, but not quite wild either.“That got me thinking about cat diet, which then made me think, wait a minute, why do we feed domestic cats fish?” Dr. Sykes asked.Cats and ChristianityCould Christianity have something to do with it?“I think that monks start keeping cats for the first time, at least in Britain, as domestic pets,” she explained. “And they keep them because they want to have cats to eat the mice that eat the documents that they’re writing. And of course, monks are eating fish because they’re required to fast all the time.”Perhaps, she said, the monks fed the cats fish. The practice spread. And now an entire separate fishery catches fish for cat food.That worries Dr. Sykes because of its environmental impact. She says shoppers don’t put the same pressure for sustainability on the cat food fleets that they do on fisheries providing food for people.She began to wonder more generally: “What is it that encourages people to feed animals in the first place? What are the drivers of this throughout time and across cultures?”The four colleagues who joined Dr. Sykes in this project are: Angela Cassidy, also at the University of Exeter, who researches government policy on animals and has written about the internecine wars over the culling of badgers in Britain; Gary Marvin, an anthropologist at the University of Roehampton, who holds one of the world’s few professorships in human-animal studies; Stuart Black, a geochemist at the University of Reading; and Andrew Kitchener, principal curator of vertebrates at National Museums Scotland.The group is limiting its research geographically to Britain, for practical and logistical reasons. Its attention is mainly focused on the roles played by birds and cats in human life, as pets, pests, wild animals and zoo animals. In each case, they are asking the same broad questions about the origin of and reason behind various feeding methods, and what needs to change, if anything.For instance, Dr. Sykes will be looking at the archaeological records of cats from Roman settlements. Dr. Black will be studying the isotopes in modern and ancient cat bones to determine what cats were eating. Did monks’ cats in fact eat a lot of fish? He has already proved his technique on modern cats. “We can tell a fishy cat from a meaty cat,” he said. “In fact we can tell an Iams cat from a Whiskers cat,” although he concedes that knowledge may not be so useful in studying felines from the Middle Ages.Guy BilloutDr. Kitchener can look at old cat skeletons from Roman times and see that wildcats, now restricted to a small population in Scotland, were living in human settlements. Dr. Cassidy may look at political policies on feeding stray cats.Dr. Marvin said he would be working with postdoctoral researchers employed through the grant to look at cultural artifacts and historical literature to gauge how human attitudes toward cats have changed. He is also working with another postdoctoral researcher in Italy who will pursue anthropological studies among women who feed the feral cats of the coliseum in Rome. This interdisciplinary approach is very important, Dr. Marvin said. “To be in a room where a geneticist can be talking to an anthropologist and actually helping to answer questions, or ask more interesting questions — I think it’s quite a feat.”The feeding of birds suggests numerous avenues of research such as where, when, how and why it began. Also how is it that people come to view some birds as beloved but disdain others?And that in turn brings up the deep philosophical question of squirrels. In Britain, Dr. Marvin said, people spend somewhere around 200 million pounds feeding birds, presumably because they like them, and want to be close to nature. But they don’t like pigeons. And squirrels are beyond the pale. “You’ve got good and bad creatures in your back garden,” he said.Dr. Black’s isotope work is key to the interdisciplinary approach of this research, which is unusual, he said, because, “it’s a humanities-driven project.” The archaeologists, anthropologists and sociologists pose questions that he can help answer.For example, in the 1500s in England, laws known as the vermin acts set bounties for killing many animals, not just rats and mice. “There were things like crows, red kites, lots of birds of prey,” Dr. Black said. What caused the change in perspective? What were people thinking? Searching texts and literature from the time may bring some answers. But one idea is that the cold temperatures of the time, known as the little ice age, made food scarce and caused animals that normally might have been foraging in the wild to turn to human settlements to steal food or prowl for refuse.Studying old bone samples and comparing them to modern bones will show, for instance, if birds of prey in the 1500s depended more on human food than on traditional forage. Old, excavated raptor bones are plentiful to examine because 16th-century British citizens empowered by the vermin acts would kill the birds and toss them on garbage heaps.Chimp tea partiesIn addition, the project is taking one look at zoo inhabitants that is not simply a question of what tigers or koalas should eat. For years a British brand of tea, PG Tips, promoted its product with television advertisements that featured dressed up chimps having tea, with crumpets and scones, of course.The chimps lived at the Twycross Zoo, although chimp tea parties were common at zoos all over England. The zoo was founded in the 1960s by “two women who were mad about primates,” Lisa Gillespie, the zoo’s research and conservation manager said in an interview. “The ladies, as they were called,” she said, had trained the chimps for parties at the zoo and for advertisements, prompting the tea company to approach them. Income from those commercials greatly helped the zoo in its early days.“The animals ate human food, tea with milk in it, cake,” Ms. Gillespie said. Because adult chimps are too aggressive to keep as pets or use in advertisements, the zoo featured babies under 3 years old. Primatologists, zookeepers and the Twycross founders later acknowledged the harm in using the chimps that way, both from high sugar foods and from interfering with their natural behavioral development as chimpanzees. They were retired to the Twycross Zoo. With no tea or parties or costumes. The last of the PG Tips chimps to die was a female named Choppers in 2016.The chimps are, however, now unwittingly helping science. The National Museum of Scotland, where Dr. Kitchener works, collected the full skeletons of the PG Tips chimps to add to their trove of animal remains from other zoos and the wild.In studying the skeletons of Choppers and the other tea party chimps, Dr. Kitchener and other researchers identified signs of illness, probably related to what they were fed.Dr. Black is using isotope analysis to nail down the nutritional profile of the tea party chimps. The project is partnering with the Powell-Cotton Museum in Kent, which has a large collection of remains of wild chimps.He and Dr. Sykes have also been looking at changes in wildcats in Britain and their diet over time, and studying the bones of wild squirrels that were fed peanuts to help keep the population going. In adapting to the diet, the squirrels may not have developed the same jaw muscles as squirrels that have to struggle with pine cones, he said. Adaptations to changing diets for animals that live around or near humans can result in significant skeletal changes, he said, which raises questions about some physical changes that are thought to accompany domestication in different animals. Animals might have adapted to living around humans long before they became what we think of as domesticated. “So did the change come before they were domesticated or did the change come because they were domesticated?” he asked.The group will largely restrict itself to the last 2,000 years, but Dr. Black said some detours are irresistible, like the Tomb of the Eagles, a 5,000-year-old stone-age site in the Orkney Islands known officially as the Ibister Chambered Cairn. The cairn, or tomb, held about 16,000 human bones, and the remains of about 30 white-tailed sea eagles, Dr. Black said. “They were deposited over quite a significant period of time,” he said, “so it was people coming back, putting eagle remains in there.”He said: “The key question that nobody has really answered at the moment is whether people went out and killed and then deposited them as a sort of an offering. There is a suggestion that they may have been pets.” If that were the case, the eagles would have probably been eating a different diet than wild eagles that were foraging at sea.Dr. Sykes sees much of the human habit of feeding animals in the light of domestication, which she says happened as much through the process of humans feeding animals as it did through catching and corralling them to eat. That seems clear enough with our close companions, dogs and cats.It also seems that some animals that we now eat, like chickens and rabbits, may have first come into our lives not as food, but as eaters.And, she said, “domestication is not this thing that happened way back when, in this kind of neolithic moment where everybody got together and goes, we’re going to domesticate animals. I just don’t buy it. I think it’s something that has not only continued throughout time, but it’s really accelerating.”Bird feeding is just one example, and that sets off warning bells for her, because domestication and extinction often go together even if the cause and effect isn’t clear.The aurochs gave way to cattle. There are plenty of domestic cats in Britain, but just a few Scottish wildcats. Wolves are still here but not the wolves that dogs descended from. They are extinct. And modern wolves are just hanging on, while dogs might number a billion. Their future, at least in terms of numbers, is bright. As long as there are people, there will be dogs. No one knows what they will look like, and whether we will have to brush their teeth day and night, and spend a fortune on their haircuts. But they will be here.The same cannot be said of wolves. And as wild creatures go extinct, we all lose.

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A New Bird Flu Jumps to Humans. So Far, It's Not a Problem

Covid fuels the current virus pandemic, but the world is full of flu viruses waiting in the wings. And they keep changing unpredictably.When a bird flu virus struck a major poultry farm in Russia earlier this year, it was a reminder that the coronavirus causing the pandemic was not the only dangerous virus out there.The authorities quickly tested the birds and moved into high gear, killing 800,000 chickens, disposing of the carcasses and cleaning the farm to stop the potential spread to other chicken farms. But they were also concerned for humans.They tested the birds and sequenced the virus, determining that it was the H5N8 strain of avian flu, highly dangerous to both wild and domestic birds. It is established in Asia and has been increasingly causing deadly outbreaks in birds in Europe. H5N8 viruses have infected some poultry flocks in the United States, but the viruses come from a different though related lineage of virus, distinct from the current H5N8 viruses in Asia and Europe. Flu viruses combine and mutate frequently in unpredictable ways.In the short period from Dec. 25, 2020, to Jan. 14 of this year, more than seven million birds were lost to H5N8 outbreaks in Europe and Asia. Europe alone had 135 outbreaks among poultry and 35 among wild birds. Of course, to put the numbers in context, humans consume about 65 billion chickens each year, and one estimate puts the number of chickens on the globe at any one time at 23 billion.As damaging as H5N8 has been to birds, it had never infected people. Until February. The Russian health authorities also tested about 200 of the people involved in the cleanup of the farm in Astrakhan, using nasal swabs and later blood tests for antibodies. They reported that for the first time, H5N8 had jumped to people. Seven of the workers appeared to have been infected with the virus, although none of them became ill. Only one of those seven cases, however, was confirmed by genetically sequencing the virus.Nonetheless, the potential danger of the new virus and its jump to humans set off alarm bells for Dr. Daniel R. Lucey, a physician and a specialist in pandemics at Georgetown University.A duck breeding farm in Letavertes, Hungary, were birds were being culled after the H5N8 virus was detected there in January 2020.Zsolt Czegledi/MTI, via Associated PressHe began writing about the Astrakahn event in a blog for other infectious disease experts as soon as it was publicized. He reported that during a television interview, a Russian public health official said the H5N8 virus was likely to evolve into human-to-human transmission. That possibility was frightening.“The W.H.O. finally put out a report Feb. 26,” he said. But it did not frame the event as particularly alarming because the virus was not causing human disease, and the report judged the risk of human-to-human transmission as low, despite the Russian official’s comment.To Dr. Lucey, no one else seemed to be taking the infection of humans with H5N8 as “of any concern.” He added, “I think it’s of concern.”Other scientists said they were not as worried.Dr. Florian Krammer, a flu researcher at the Icahn School of Medicine at Mt. Sinai, said he was more concerned about other avian flu viruses like H5N1 that have already shown themselves to be dangerous to people. Another avian influenza virus, H7N9, infected people for the first time in 2013. There have been more than 1,500 confirmed cases and more than 600 deaths since then. Since 2017 there have been only three confirmed cases and the virus does not jump easily from person to person.It is always possible that any virus can evolve human-to-human transmission, as well as become more dangerous. But H5N8 would have both hurdles to jump. Compared to other viral threats, Dr. Krammer said, “I’m not worried.”Dr. Richard J. Webby, a flu specialist at the St. Jude Graduate School of Biomedical Sciences and director of the W.H.O.’s Collaborating Centre for Studies on the Ecology of Influenza in Animals and Birds, said that all of the H5 viruses are of concern because some of them have infected and killed people. But, he said, “They all have the same sort of binding capacity to human cells, which is limited,” he said. Flu viruses use a slightly different way to attach to cells in birds than to cells in humans and being good at one usually means not being good at the other.Dr. Webby also said that while seven infections would certainly be of concern, only one infection has been confirmed. The tests of the other six involved nasal swabs and blood antibody tests. In people with no symptoms, he said, nasal swabs can simply indicate that they had breathed in virus. That would not mean it had infected them.Blood antibody tests also have a potential for error, he said, and may not be able to distinguish exposure to one flu virus from another.Nor did he see any scientific basis for suggesting that H5N8 is more likely than any other bird flu to evolve human-to-human transmission. But any virus could evolve that ability.Dr. Lucey said that he was heartened to see that the U.S. Centers for Disease Control and Prevention had prepared a candidate vaccine for H5N8 before it had infected humans. Candidate vaccines are simply first steps in planning for potential problems, and have not been through any testing. They exist for many viruses.“Humans should be routinely tested those for the virus, right at the time of the outbreak in birds,” Dr. Lucey said. He favors the protocol followed in Astrakahn, and argues that for any outbreak among birds, public health authorities should test people who are exposed to sick birds with nasopharyngeal swabs and an antibody test, followed by other antibody tests a few weeks later.An upcoming editorial in the journal Travel Medicine and Infectious Disease also takes up the Astrakahn incident and calls for increased monitoring of all H5 viruses.

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San Diego Zoo Apes Get an Experimental Covid Vaccine

#masthead-section-label, #masthead-bar-one { display: none }The Coronavirus OutbreakliveLatest UpdatesMaps and CasesRisk Near YouVaccine RolloutNew Variants TrackerAdvertisementContinue reading the main storyCovid-19 Live Updates: Global Vaccine Push Fuels a New Race, This Time for SyringesSan Diego Zoo apes get an experimental animal vaccine against coronavirus.March 4, 2021, 9:56 a.m. ETMarch 4, 2021, 9:56 a.m. ETSome gorillas in a troop at the San Diego Zoo tested positive for the coronavirus in January. Zoo officials have been using an experimental vaccine on other apes, like orangutans and bonobos. Credit…Ken Bohn/San Diego Zoo Global, via, via ReutersThe San Diego Zoo has given nine apes an experimental coronavirus vaccine developed by Zoetis, a major veterinary pharmaceuticals company.In January, a troop of gorillas at the zoo’s Safari Park tested positive for the virus. All are recovering, but even so, the zoo requested help from Zoetis in vaccinating other apes. The company provided an experimental vaccine that was initially developed for pets and is now being tested in mink.Nadine Lamberski, a conservation and wildlife health officer at San Diego Zoo Global, said the zoo vaccinated four orangutans and five bonobos with the experimental vaccine, which is not designed for use in humans. Among the vaccinated orangutans was an ape named Karen, who made history in 1994 when she became the first orangutan to have open-heart surgery.Dr. Lamberski said one gorilla at the zoo was also scheduled to be vaccinated, but the gorillas at the wildlife park were a lower priority because they had already tested positive for infection and had recovered. She said she would vaccinate the gorillas at the wildlife park if the zoo received more doses of the vaccine.Mahesh Kumar, senior vice president of global biologics for Zoetis, said the company is increasing production, primarily for its pursuit of a license for a mink vaccine, and will provide more doses to the San Diego and other zoos when possible. “We have already received a number of requests,” he said.Infection of apes is a major concern for zoos and conservationists. They easily fall prey to human respiratory infections, and common cold viruses have caused deadly outbreaks in chimpanzees in Africa. Genome research has suggested that chimpanzees, gorillas and other apes will be susceptible to SARS-CoV-2, the virus that has caused the pandemic. Lab researchers are using some monkeys, like macaques, to test drugs and vaccines and develop new treatments for the virus.The Coronavirus Outbreak

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Some Scientists Question W.H.O. Inquiry Into the Coronavirus Pandemic’s Origins

#masthead-section-label, #masthead-bar-one { display: none }The Coronavirus OutbreakliveLatest UpdatesMaps and CasesRisk Near YouVaccine RolloutNew Variants TrackerAdvertisementContinue reading the main storySupported byContinue reading the main storySome Scientists Question W.H.O. Inquiry Into the Coronavirus Pandemic’s OriginsThose who still suspect the outbreak in China may have been caused by a lab leak or accident are pressing for an independent investigation.Members of the World Health Organization’s team investigating the origins of the coronavirus arrived at the Wuhan Institute of Virology last month.Credit…Hector Retamal/Agence France-Presse — Getty ImagesMarch 4, 2021阅读简体中文版閱讀繁體中文版A small group of scientists and others who believe the novel coronavirus that spawned the pandemic could have originated from a lab leak or accident is calling for an inquiry independent of the World Health Organization’s team of independent experts sent to China last month.While many scientists involved in researching the origins of the virus continue to assert that the SARS-CoV-2 pandemic almost certainly began in a leap from bats to an intermediate animal to humans, other theories persist and have gained new visibility with the W.H.O.-led team of experts’ visit to China. Officials with the W.H.O. have said in recent interviews that it was “extremely unlikely” but not impossible that the spread of the virus was linked to some lab accident.The open letter, first reported in The Wall Street Journal and the French publication Le Monde, lists what the signers see as flaws in the joint W.H.O.-China inquiry, and state that it could not adequately address the possibility that the virus leaked from a lab. The letter further posits the type of investigation that would be adequate, including full access to records within China.The W.H.O. mission, as with everything involving China and the coronavirus, has been political from the start as the international team’s members acknowledged.Letter Seeking International Inquiry Into Origins of the CoronavirusSome scientists are calling for an investigation independent of that under way by a team of scientists and the World Health Organization into the source of the novel coronavirus outbreak in China.Read DocumentRichard Ebright, a molecular biologist at Rutgers University and one of the scientists who signed the letter, said it grew out of a series of online discussions among scientists, policy experts and others who came to be known informally as the Paris group. Many of those who signed the letter were based in France and Dr. Ebright, who has been outspoken about the need to investigate a possible laboratory leak, said such discussion had been less vigorous in the United States.He said that no one in the group thought that the virus had been intentionally created as a weapon, but they were all convinced that an origin in a lab through research or by accidental infection was as likely as a spillover occurring in nature from animals to humans.Dr. Ebright said the letter was released because the Paris group expected to see an interim report from the W.H.O. on Thursday. The letter, he added, “was communicated to high levels of the W. H.O. on Tuesday.”The Huanan seafood market, now closed, last month in Wuhan.Credit…Getty ImagesAsked to respond to the letter, Tarik Jasarevic, a spokesman for the W.H.O., replied in an email that the team of experts that had gone to China “is working on its full report as well as an accompanying summary report, which we understand will be issued simultaneously in a couple of weeks.”The open letter noted that the W.H.O.’s study was a joint effort by a team of outside experts, selected by the global health organization, who worked along with Chinese scientists, and that the team’s report must be agreed on by all. The letter emphasized that the team was denied access to some records and did not investigate laboratories in China.The Coronavirus Outbreak

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